Search: ((WFRF:(Bordet Régis)) pers:(Sala Isabel)) >
Blood DNA methylomi...
Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer's disease in the EMIF-AD study
-
- Smith, Rebecca G. (author)
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Devon, UK
-
- Pishva, Ehsan (author)
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Devon, UK; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands
-
- Kouhsar, Morteza (author)
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Devon, UK
-
show more...
-
- Imm, Jennifer (author)
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Devon, UK
-
- Dobricic, Valerija (author)
- Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany
-
- Johannsen, Peter (author)
- Danish Dementia Research Centre, Rigshospitalet, Copenhagen, Denmark
-
- Wittig, Michael (author)
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany
-
- Franke, Andre (author)
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany
-
- Vandenberghe, Rik (author)
- Laboratory for Cognitive Neurology, KU Leuven, Leuven Brain Institute, Leuven, Belgium
-
- Schaeverbeke, Jolien (author)
- Laboratory for Cognitive Neurology, KU Leuven, Leuven Brain Institute, Leuven, Belgium
-
- Freund-Levi, Yvonne, 1956- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden; Department of Geriatrics, Södertälje Hospital, Södertälje, Sweden
-
- Frölich, Lutz (author)
- Department of Geriatric Psychiatry, Central Institut of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany
-
- Scheltens, Philip (author)
- Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
-
- Teunissen, Charlotte E. (author)
- Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
-
- Frisoni, Giovanni (author)
- Memory center, Geneva University and University Hospitals; AMYPAD consortium, Geneva, Switzerland
-
- Blin, Olivier (author)
- Aix-Marseille University-CNRS, Marseille, France
-
- Richardson, Jill C. (author)
- Neuroscience Therapeutic Area, GlaxoSmithKline R&D, Stevenage, Hertfordshire, UK
-
- Bordet, Régis (author)
- Université de Lille, Lille, Cedex, France
-
- Engelborghs, Sebastiaan (author)
- Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium; Neuroprotection & Neuromodulation (NEUR) Research Group, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Jette, Brussels, Belgium
-
- de Roeck, Ellen (author)
- Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
-
- Martinez-Lage, Pablo (author)
- Center for Research and Advanced Therapies, Fundación CITA-Alzhéimer Fundazioa, San Sebastian, Gipuzkoa, Spain
-
- Altuna, Miren (author)
- Center for Research and Advanced Therapies, Fundación CITA-Alzhéimer Fundazioa, San Sebastian, Gipuzkoa, Spain
-
- Tainta, Mikel (author)
- Center for Research and Advanced Therapies, Fundación CITA-Alzhéimer Fundazioa, San Sebastian, Gipuzkoa, Spain
-
- Lleó, Alberto (author)
- Servicio de Neurología, Centre of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Hospital Sant Pau, Barcelona, Spain
-
- Sala, Isabel (author)
- Servicio de Neurología, Centre of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Hospital Sant Pau, Barcelona, Spain
-
- Popp, Julius (author)
- University Hospital of Psychiatry Zürich, University of Zürich, Zürich, Switzerland
-
- Peyratout, Gwendoline (author)
- Department of Psychiatry, University Hospital of Lausanne (CHUV), Lausanne, Switzerland
-
- Winchester, Laura (author)
- Department of Psychiatry, University of Oxford, Oxford, UK
-
- Nevado-Holgado, Alejo (author)
- Department of Psychiatry, University of Oxford, Oxford, UK
-
- Verhey, Frans (author)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands
-
- Tsolaki, Magda (author)
- 1st Department of Neurology, School of Medicine, Laboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation, Aristotle University of Thessaloniki, and Alzheimer Hellas, Thessaloniki, Greece
-
- Andreasson, Ulf (author)
- Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden
-
- Blennow, Kaj (author)
- Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden; Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France; Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, PR China
-
- Zetterberg, Henrik (author)
- Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK; UK Dementia Research Institute at UCL, London, UK; Hong Kong Center for Neurodegenerative Diseases, N.T., Shatin, Hong Kong, China; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA
-
- Streffer, Johannes (author)
- Translational Medicine Neuroscience, UCB Biopharma SRL, Brussels, Belgium
-
- Vos, Stephanie J. B. (author)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands
-
- Lovestone, Simon (author)
- Department of Psychiatry, University Hospital of Lausanne (CHUV), Lausanne, Switzerland; Johnson & Johnson Innovative Medicines, Beerse, Belgium
-
- Visser, Pieter Jelle (author)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
-
- Bertram, Lars (author)
- Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany
-
- Lunnon, Katie (author)
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Devon, UK
-
show less...
-
(creator_code:org_t)
- 2024
- 2024
- English.
-
In: Alzheimer's & Dementia. - : John Wiley & Sons. - 1552-5260 .- 1552-5279.
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- INTRODUCTION: We investigated blood DNA methylation patterns associated with 15 well-established cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) pathophysiology, neuroinflammation, and neurodegeneration.METHODS: We assessed DNA methylation in 885 blood samples from the European Medical Information Framework for Alzheimer's Disease (EMIF-AD) study using the EPIC array.RESULTS: We identified Bonferroni-significant differential methylation associated with CSF YKL-40 (five loci) and neurofilament light chain (NfL; seven loci) levels, with two of the loci associated with CSF YKL-40 levels correlating with plasma YKL-40 levels. A co-localization analysis showed shared genetic variants underlying YKL-40 DNA methylation and CSF protein levels, with evidence that DNA methylation mediates the association between genotype and protein levels. Weighted gene correlation network analysis identified two modules of co-methylated loci correlated with several amyloid measures and enriched in pathways associated with lipoproteins and development.DISCUSSION: We conducted the most comprehensive epigenome-wide association study (EWAS) of AD-relevant CSF biomarkers to date. Future work should explore the relationship between YKL-40 genotype, DNA methylation, and protein levels in the brain.HIGHLIGHTS: Blood DNA methylation was assessed in the EMIF-AD MBD study. Epigenome-wide association studies (EWASs) were performed for 15 Alzheimer's disease (AD)-relevant cerebrospinal fluid (CSF) biomarker measures. Five Bonferroni-significant loci were associated with YKL-40 levels and seven with neurofilament light chain (NfL). DNA methylation in YKL-40 co-localized with previously reported genetic variation. DNA methylation potentially mediates the effect of single-nucleotide polymorphisms (SNPs) in YKL-40 on CSF protein levels.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease (AD)
- DNA methylation
- YKL‐40
- amyloid
- biomarker
- blood
- cerebrospinal fluid (CSF)
- epigenetics
- epigenome‐wide association study (EWAS)
- genome‐wide association study (GWAS)
- methylation quantitative trait loci (mQTL)
- mild cognitive impairment (MCI)
- neurofilament light (NfL)
- protein quantitative trait loci (pQTL)
- tau
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Smith, Rebecca G ...
-
Pishva, Ehsan
-
Kouhsar, Morteza
-
Imm, Jennifer
-
Dobricic, Valeri ...
-
Johannsen, Peter
-
show more...
-
Wittig, Michael
-
Franke, Andre
-
Vandenberghe, Ri ...
-
Schaeverbeke, Jo ...
-
Freund-Levi, Yvo ...
-
Frölich, Lutz
-
Scheltens, Phili ...
-
Teunissen, Charl ...
-
Frisoni, Giovann ...
-
Blin, Olivier
-
Richardson, Jill ...
-
Bordet, Régis
-
Engelborghs, Seb ...
-
de Roeck, Ellen
-
Martinez-Lage, P ...
-
Altuna, Miren
-
Tainta, Mikel
-
Lleó, Alberto
-
Sala, Isabel
-
Popp, Julius
-
Peyratout, Gwend ...
-
Winchester, Laur ...
-
Nevado-Holgado, ...
-
Verhey, Frans
-
Tsolaki, Magda
-
Andreasson, Ulf
-
Blennow, Kaj
-
Zetterberg, Henr ...
-
Streffer, Johann ...
-
Vos, Stephanie J ...
-
Lovestone, Simon
-
Visser, Pieter J ...
-
Bertram, Lars
-
Lunnon, Katie
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Alzheimer's & De ...
- By the university
-
Örebro University