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Sökning: WFRF:(Nevado Holgado Alejo J) > Validation of Plasm...

  • Westwood, SarahDepartment of Psychiatry, University of Oxford, UK (författare)

Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • IOS Press,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-79728
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-79728URI
  • https://doi.org/10.3233/JAD-190434DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143257872URI
  • https://gup.ub.gu.se/publication/291090URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • We have previously investigated, discovered, and replicated plasma protein biomarkers for use to triage potential trials participants for PET or cerebrospinal fluid measures of Alzheimer's disease (AD) pathology. This study sought to undertake validation of these candidate plasma biomarkers in a large, multi-center sample collection. Targeted plasma analyses of 34 proteins with prior evidence for prediction of in vivo pathology were conducted in up to 1,000 samples from cognitively healthy elderly individuals, people with mild cognitive impairment, and in patients with AD-type dementia, selected from the EMIF-AD catalogue. Proteins were measured using Luminex xMAP, ELISA, and Meso Scale Discovery assays. Seven proteins replicated in their ability to predict in vivo amyloid pathology. These proteins form a biomarker panel that, along with age, could significantly discriminate between individuals with high and low amyloid pathology with an area under the curve of 0.74. The performance of this biomarker panel remained consistent when tested in apolipoprotein E ɛ4 non-carrier individuals only. This blood-based panel is biologically relevant, measurable using practical immunocapture arrays, and could significantly reduce the cost incurred to clinical trials through screen failure.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Baird, Alison L.Department of Psychiatry, University of Oxford, UK (författare)
  • Anand, Sneha N.Department of Psychiatry, University of Oxford, UK (författare)
  • Nevado-Holgado, Alejo J.Department of Psychiatry, University of Oxford, UK (författare)
  • Kormilitzin, AndreyDepartment of Psychiatry, University of Oxford, UK (författare)
  • Shi, LiuDepartment of Psychiatry, University of Oxford, UK (författare)
  • Hye, AbdulMaurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK (författare)
  • Ashton, Nicholas J.Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xashtn (författare)
  • Morgan, Angharad R.Dementia Research Institute Cardiff, Cardiff University, Cardiff, UK (författare)
  • Bos, IsabelleDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands (författare)
  • Vos, Stephanie J. B.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands (författare)
  • Baker, SusanJanssen R&D, Titusville, NJ, USA (författare)
  • Buckley, Noel J.Department of Psychiatry, University of Oxford, UK (författare)
  • Ten Kate, MaraAlzheimer Center, VU University Medical Center, Amsterdam, the Netherlands (författare)
  • Scheltens, PhilipAlzheimer Center, VU University Medical Center, Amsterdam, the Netherlands (författare)
  • Teunissen, Charlotte E.Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands (författare)
  • Vandenberghe, RikUniversity Hospital Leuven, Leuven, Belgium (författare)
  • Gabel, SilvyUniversity Hospital Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Belgium (författare)
  • Meersmans, KarenUniversity Hospital Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Belgium (författare)
  • Engelborghs, SebastiaanDepartment of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, University of Antwerp, Antwerp, Belgium; Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium (författare)
  • De Roeck, Ellen E.Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, University of Antwerp, Antwerp, Belgium; Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium (författare)
  • Sleegers, KristelCenter for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Belgium (författare)
  • Frisoni, Giovanni B.University of Geneva, Geneva, Switzerland; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy (författare)
  • Blin, OlivierAIX Marseille University, INS, Ap-Hm, Marseille, France (författare)
  • Richardson, Jill C.Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage, UK (författare)
  • Bordet, RégisUniversity of Lille, Inserm, CHU Lille, France (författare)
  • Molinuevo, José L.Alzheimer's Disease & Other Cognitive Disorders Unit, Hopsital Clínic-IDIBAPS, Barcelona, Spain; Barcelona Beta Brain Research Center, Unversitat Pompeu Fabra, Barcelona, Spain (författare)
  • Rami, LorenaBarcelona Beta Brain Research Center, Unversitat Pompeu Fabra, Barcelona, Spain (författare)
  • Wallin, AndersInstitute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (författare)
  • Kettunen, PetronellaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xketpe (författare)
  • Tsolaki, Magda1st Department of Neurology, AHEPA University Hospital, Makedonia, Thessaloniki, Greece (författare)
  • Verhey, FransDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands (författare)
  • Lléo, AlbertoHospital de la Santa Creu i Sant Pau, Barcelona, Spain (författare)
  • Sala, IsabelDepartment of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (författare)
  • Popp, JuliusKarolinska Institutet (författare)
  • Peyratout, GwendolineUniversity Hospital of Lausanne, Lausanne, Switzerland (författare)
  • Martinez-Lage, PabloGeriatric Psychiatry, Department of Mental Health and Psychiatry, Geneva University Hospitals, Geneva, Switzerland (författare)
  • Tainta, MikelCITA-Alzheimer Foundation, San Sebastian, Spain (författare)
  • Johannsen, PeterDanish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark (författare)
  • Freund-Levi, Yvonne,1956-Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden; Maurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK(Swepub:oru)yfi (författare)
  • Frölich, LutzDepartment of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany (författare)
  • Dobricic, ValerijaLübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany (författare)
  • Legido-Quigley, CristinaKings College London, London, UK; The Systems Medicine Group, Steno Diabetes Center, Gentofte, Denmark (författare)
  • Bertram, LarsLübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany; Department of Psychology, University of Oslo, Oslo, Norway (författare)
  • Barkhof, FrederikDepartment of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherland; UCL Institutes of Neurology and Healthcare Engineering, London, UK (författare)
  • Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (författare)
  • Morgan, B. PaulDementia Research Institute Cardiff, Cardiff University, Cardiff, UK (författare)
  • Streffer, JohannesCenter for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium; UCB, Braine-l'Alleud, Belgium, formerly Janssen R&D, LLC. Beerse, Belgium at the Time of Study Conduct (författare)
  • Visser, Pieter JelleDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands; Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands (författare)
  • Lovestone, SimonDepartment of Psychiatry, University of Oxford, UK; Janssen R&D, UK (författare)
  • Department of Psychiatry, University of Oxford, UKMaurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Alzheimer's Disease: IOS Press74:1, s. 213-2251387-28771875-8908

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