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Validation of Plasm...
Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort
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- Westwood, Sarah (författare)
- Department of Psychiatry, University of Oxford, UK
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- Baird, Alison L. (författare)
- Department of Psychiatry, University of Oxford, UK
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- Anand, Sneha N. (författare)
- Department of Psychiatry, University of Oxford, UK
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- Nevado-Holgado, Alejo J. (författare)
- Department of Psychiatry, University of Oxford, UK
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- Kormilitzin, Andrey (författare)
- Department of Psychiatry, University of Oxford, UK
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- Shi, Liu (författare)
- Department of Psychiatry, University of Oxford, UK
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- Hye, Abdul (författare)
- Maurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK
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- Ashton, Nicholas J. (författare)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Morgan, Angharad R. (författare)
- Dementia Research Institute Cardiff, Cardiff University, Cardiff, UK
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- Bos, Isabelle (författare)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands
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- Vos, Stephanie J. B. (författare)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands
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- Baker, Susan (författare)
- Janssen R&D, Titusville, NJ, USA
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- Buckley, Noel J. (författare)
- Department of Psychiatry, University of Oxford, UK
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- Ten Kate, Mara (författare)
- Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands
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- Scheltens, Philip (författare)
- Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands
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- Teunissen, Charlotte E. (författare)
- Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands
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- Vandenberghe, Rik (författare)
- University Hospital Leuven, Leuven, Belgium
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- Gabel, Silvy (författare)
- University Hospital Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Belgium
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- Meersmans, Karen (författare)
- University Hospital Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Belgium
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- Engelborghs, Sebastiaan (författare)
- Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, University of Antwerp, Antwerp, Belgium; Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium
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- De Roeck, Ellen E. (författare)
- Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, University of Antwerp, Antwerp, Belgium; Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium
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- Sleegers, Kristel (författare)
- Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Belgium
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- Frisoni, Giovanni B. (författare)
- University of Geneva, Geneva, Switzerland; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
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- Blin, Olivier (författare)
- AIX Marseille University, INS, Ap-Hm, Marseille, France
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- Richardson, Jill C. (författare)
- Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage, UK
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- Bordet, Régis (författare)
- University of Lille, Inserm, CHU Lille, France
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- Molinuevo, José L. (författare)
- Alzheimer's Disease & Other Cognitive Disorders Unit, Hopsital Clínic-IDIBAPS, Barcelona, Spain; Barcelona Beta Brain Research Center, Unversitat Pompeu Fabra, Barcelona, Spain
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- Rami, Lorena (författare)
- Barcelona Beta Brain Research Center, Unversitat Pompeu Fabra, Barcelona, Spain
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- Wallin, Anders (författare)
- Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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- Kettunen, Petronella (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Tsolaki, Magda (författare)
- 1st Department of Neurology, AHEPA University Hospital, Makedonia, Thessaloniki, Greece
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- Verhey, Frans (författare)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands
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- Lléo, Alberto (författare)
- Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
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- Sala, Isabel (författare)
- Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
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- Popp, Julius (författare)
- Karolinska Institutet
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- Peyratout, Gwendoline (författare)
- University Hospital of Lausanne, Lausanne, Switzerland
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- Martinez-Lage, Pablo (författare)
- Geriatric Psychiatry, Department of Mental Health and Psychiatry, Geneva University Hospitals, Geneva, Switzerland
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- Tainta, Mikel (författare)
- CITA-Alzheimer Foundation, San Sebastian, Spain
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- Johannsen, Peter (författare)
- Danish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
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- Freund-Levi, Yvonne, 1956- (författare)
- Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden; Maurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK
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- Frölich, Lutz (författare)
- Department of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany
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- Dobricic, Valerija (författare)
- Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany
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- Legido-Quigley, Cristina (författare)
- Kings College London, London, UK; The Systems Medicine Group, Steno Diabetes Center, Gentofte, Denmark
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- Bertram, Lars (författare)
- Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany; Department of Psychology, University of Oslo, Oslo, Norway
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- Barkhof, Frederik (författare)
- Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherland; UCL Institutes of Neurology and Healthcare Engineering, London, UK
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Morgan, B. Paul (författare)
- Dementia Research Institute Cardiff, Cardiff University, Cardiff, UK
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- Streffer, Johannes (författare)
- Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium; UCB, Braine-l'Alleud, Belgium, formerly Janssen R&D, LLC. Beerse, Belgium at the Time of Study Conduct
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- Visser, Pieter Jelle (författare)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands; Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands
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- Lovestone, Simon (författare)
- Department of Psychiatry, University of Oxford, UK; Janssen R&D, UK
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(creator_code:org_t)
- IOS Press, 2020
- 2020
- Engelska.
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Ingår i: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 74:1, s. 213-225
- Relaterad länk:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- We have previously investigated, discovered, and replicated plasma protein biomarkers for use to triage potential trials participants for PET or cerebrospinal fluid measures of Alzheimer's disease (AD) pathology. This study sought to undertake validation of these candidate plasma biomarkers in a large, multi-center sample collection. Targeted plasma analyses of 34 proteins with prior evidence for prediction of in vivo pathology were conducted in up to 1,000 samples from cognitively healthy elderly individuals, people with mild cognitive impairment, and in patients with AD-type dementia, selected from the EMIF-AD catalogue. Proteins were measured using Luminex xMAP, ELISA, and Meso Scale Discovery assays. Seven proteins replicated in their ability to predict in vivo amyloid pathology. These proteins form a biomarker panel that, along with age, could significantly discriminate between individuals with high and low amyloid pathology with an area under the curve of 0.74. The performance of this biomarker panel remained consistent when tested in apolipoprotein E ɛ4 non-carrier individuals only. This blood-based panel is biologically relevant, measurable using practical immunocapture arrays, and could significantly reduce the cost incurred to clinical trials through screen failure.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer’s disease
- amyloid-β
- biomarkers
- plasma
- proteomics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Westwood, Sarah
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Baird, Alison L.
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Anand, Sneha N.
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Nevado-Holgado, ...
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Kormilitzin, And ...
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Shi, Liu
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visa fler...
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Hye, Abdul
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Ashton, Nicholas ...
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Morgan, Angharad ...
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Bos, Isabelle
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Vos, Stephanie J ...
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Baker, Susan
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Buckley, Noel J.
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Ten Kate, Mara
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Scheltens, Phili ...
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Teunissen, Charl ...
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Vandenberghe, Ri ...
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Gabel, Silvy
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Meersmans, Karen
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Engelborghs, Seb ...
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De Roeck, Ellen ...
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Sleegers, Kriste ...
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Frisoni, Giovann ...
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Blin, Olivier
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Richardson, Jill ...
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Bordet, Régis
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Molinuevo, José ...
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Rami, Lorena
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Wallin, Anders
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Kettunen, Petron ...
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Tsolaki, Magda
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Verhey, Frans
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Lléo, Alberto
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Sala, Isabel
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Popp, Julius
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Peyratout, Gwend ...
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Martinez-Lage, P ...
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Tainta, Mikel
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Johannsen, Peter
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Freund-Levi, Yvo ...
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Frölich, Lutz
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Dobricic, Valeri ...
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Legido-Quigley, ...
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Bertram, Lars
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Barkhof, Frederi ...
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Zetterberg, Henr ...
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Morgan, B. Paul
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Streffer, Johann ...
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Visser, Pieter J ...
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Lovestone, Simon
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Klinisk laborato ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Journal of Alzhe ...
- Av lärosätet
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Örebro universitet
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Karolinska Institutet
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Göteborgs universitet