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Tobacco exposure in...
Tobacco exposure in utero and childhood asthma and wheeze - a register-based cohort study
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- Lundholm, Cecilia (författare)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Gunnerbeck, Anna (författare)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet; Neuropediatric Unit, Department of Women’s and Children’s Health, Karolinska Institutet; Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden
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- D'Onofrio, Brian (författare)
- Department of Psychological and Brain Sciences, Indiana University, Bloomington, United States of America
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- Larsson, Henrik, 1975- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Pershagen, Goran (författare)
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Almqvist, Catarina (författare)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet; Astrid Lindgren Children’s Hospital, Lung and Allergy Unit, Karolinska University Hospital, Stockholm, Sweden
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(creator_code:org_t)
- European Respiratory Society, 2019
- 2019
- Engelska.
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Ingår i: European Respiratory Journal. - : European Respiratory Society. - 0903-1936 .- 1399-3003. ; 54:Suppl. 63
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Previous studies have found associations between smoking during pregnancy (SDP) and childhood asthma/wheeze. Although nicotine has been suggested as a causal agent, the mechanism is unclear. In Sweden, oral moist snuff (snus) is a common form of tobacco, with high nicotine levels, but no combustion.Aim: To estimate the association between tobacco use in pregnancy, both smoking and snus, and asthma/wheeze in the child, to examine the role of nicotine.Methods: Our cohort included 897 975 children, born in Sweden 2005-2012. Information on SDP and snus use came from the Medical Birth Registry. We based the asthma/wheeze outcome on diagnoses and drugs from national health registers, as incident asthma at age 0-7 yrs and prevalent asthma at ages 2-6 yrs.Results: For the association of SDP and asthma/wheeze, we saw a pattern with higher hazard ratios around 5 and 18 months of age (Figure 1). Snus did not show the same pattern. Prevalent asthma, showed the strongest association with SDP at age 2 yrs (adjOR=1.22 95% CI: 1.17-1.28). The corresponding estimates for snus was adjOR=1.06 (95% CI: 0.96-1.18).Conclusion: We saw an association between SDP and asthma at early age, but the association with snus was much weaker. The results suggest that nicotine is not a causal agent in the SDP – asthma association.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Children
- Smoking
- Environment
Publikations- och innehållstyp
- vet (ämneskategori)
- art (ämneskategori)
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