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The risk of epileps...
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Canova, CristinaDepartment of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Padua, Italy
(författare)
The risk of epilepsy in children with celiac disease : a population-based cohort study
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-03-22
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Blackwell Publishing,2020
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-79957
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-79957URI
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https://doi.org/10.1111/ene.14160DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:143243010URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agency:University of Padua F.S. 4.18.01.05
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Background and purpose: The purpose was to estimate the risk of epilepsy in a cohort of young individuals with celiac disease (CD) compared to that of matched references.Methods: The cohort consists of 213,635 individuals born during 1989-2011 and residing in Friuli-Venezia Giulia (Italy). We identified 1,215 individuals affected by CD and 6,075 reference individuals matched by sex and age. Epilepsy was defined by means of hospital diagnosis or drug prescriptions. Conditional logistic regression was used to estimate the odds ratios (ORs) of having epilepsy among individuals with CD, before CD diagnosis and in the entire period, compared with those of their matched references. Cox regression was used to calculate the hazard ratios (HRs) for epilepsy diagnosed after CD diagnosis. Different definitions of epilepsy were used for sensitivity analyses.Results: Thirty-one (2.6%) individuals with CD and 78 (1.3%) reference individuals had epilepsy (adjusted OR: 2.03 95%CI: 1.33-3.10). The risk of epilepsy was increased prior to CD (adjusted OR: 2.29; 95%CI: 1.33-3.94), with similar estimates after CD diagnosis (adjusted HR 1.96; 95%CI: 0.95-4.02). The increased risk of epilepsy was not explained by a peak in epilepsy diagnosis just around CD diagnosis. Sex stratification found a significantly higher risk of epilepsy among female individuals with CD. Sensitivity analyses confirmed the positive association between CD and epilepsy.Conclusion: Children and youths with CD were at increased risk of epilepsy. Patients with epilepsy without a clear etiology should be screened for CD since an early diagnosis and treatment might improve the response to antiepileptic therapies.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ludvigsson, Jonas F.,1969-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA(Swepub:oru)jsln
(författare)
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Barbiellini Amidei, ClaudioDepartment of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Padua, Italy
(författare)
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Zanier, LorisEpidemiological Service, Health Directorate, Friuli Venezia-Giulia Region, Udine, Italy
(författare)
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Zingone, FabianaDepartment of Surgery, Oncology and Gastroenterology, Gastroenterology Section, University Hospital of Padua, Italy
(författare)
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Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Padua, ItalyInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Neurology: Blackwell Publishing27:6, s. 1089-10951351-51011468-1331
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