Early Childhood Antibiotic Treatment for Otitis Media and Other Respiratory Tract Infections Is Associated With Risk of Type 1 Diabetes: A Nationwide Register-Based Study With Sibling Analysis

Wernroth, LisaUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab (författare)

Early Childhood Antibiotic Treatment for Otitis Media and Other Respiratory Tract Infections Is Associated With Risk of Type 1 Diabetes : A Nationwide Register-Based Study With Sibling Analysis

Funding Agencies:Vetenskapsrådet (Swedish Research Council) through Swedish Initiative for Research on Microdata in the Social And Medical Sciences (SIMSAM) framework 340-2013-5867Uppsala Antibiotic Center
OBJECTIVE: The effect of early life antibiotic treatment on the risk of type 1 diabetes is debated. This study assessed this question, applying a register-based design in children up to age 10 years including a large sibling-control analysis.RESEARCH DESIGN AND METHODS: = 797,318) born in Sweden between 1 July 2005 and 30 September 2013 were included and monitored to 31 December 2014. Cox proportional hazards models, adjusted for parental and perinatal characteristics, were applied, and stratified models were used to account for unmeasured confounders shared by siblings.RESULTS: for interaction = 0.016). The association was driven by exposure to antibiotics primarily used for acute otitis media and respiratory tract infections. Further, we found an association of antibiotic prescriptions in pregnancy (22.5%) with type 1 diabetes (adjusted HR 1.15 [95% CI 1.00-1.32]). In general, sibling analysis supported these results, albeit often with statistically nonsignificant associations.CONCLUSIONS: Dispensed prescription of antibiotics, mainly for acute otitis media and respiratory tract infections, in the 1st year of life is associated with an increased risk of type 1 diabetes before age 10, most prominently in children delivered by cesarean section.

Fall, Katja,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,Clinical Epidemiology and Biostatistics,Orebro Univ, Sch Med Sci, Clin Epidemiol & Biostat, Orebro, Sweden.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.(Swepub:oru)kafl (författare)
Svennblad, BodilUppsala universitet,Medicinsk epidemiologi(Swepub:uu)bosve677 (författare)
Ludvigsson, Jonas F.,1969-Karolinska Institutet(Swepub:oru)jsln (författare)
Sjölander, ArvidKarolinska Institutet (författare)
Almqvist, CatarinaKarolinska Institutet (författare)
Fall, Tove,1979-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Uppsala Univ, Dept Med Sci, Mol Epidemiol, Uppsala, Sweden.;Uppsala Univ, Sci Life Lab, Uppsala, Sweden.(Swepub:uu)tovfa878 (författare)
Uppsala universitetUppsala kliniska forskningscentrum (UCR) (creator_code:org_t)

Ingår i:Diabetes Care: American Diabetes Association43:5, s. 991-9990149-59921935-5548

Av författaren/redakt...: Wernroth, Lisa; Fall, Katja, 197 ...; Svennblad, Bodil; Ludvigsson, Jona ...; Sjölander, Arvid; Almqvist, Catari ...; visa fler...; Fall, Tove, 1979 ...; visa färre...

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Av lärosätet: Örebro universitet; Uppsala universitet; Karolinska Institutet

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