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Comorbid disease bu...
Comorbid disease burden among MS patients 1968-2012 : A Swedish register-based cohort study
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- Smith, Kelsi A. (författare)
- Karolinska Institutet
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- Burkill, Sarah (författare)
- Clinical Epidemiology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden; Centre for Pharmacoepidemiology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden
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- Hiyoshi, Ayako, 1972- (författare)
- Stockholms universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Public Health Sciences, Stockholm University, Stockholm, Sweden,Clinical Epidemiology and Biostatistics,Institutionen för folkhälsovetenskap,Örebro University, Sweden
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- Olsson, Tomas (författare)
- Karolinska Institutet
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- Bahmanyar, Shahram (författare)
- Karolinska Institutet
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- Wormser, David (författare)
- F. Hoffmann-La Roche Ltd., Basel, Switzerland
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- Geissbühler, Yvonne (författare)
- Novartis Pharma AG, Basel, Switzerland
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- Moore, Alan (författare)
- Novartis Pharma AG, Basel, Switzerland
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- Kharat, Vineetkumar (författare)
- Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
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- Montgomery, Scott, 1961- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Clinical Epidemiology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College London, London, UK.,Clinical Epidemiology and Biostatistics
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(creator_code:org_t)
- 2020-03-12
- 2021
- Engelska.
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Ingår i: Multiple Sclerosis Journal. - : Sage Publications. - 1352-4585 .- 1477-0970. ; 27:2, s. 268-280
- Relaterad länk:
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https://doi.org/10.1...
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https://journals.sag...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: People with multiple sclerosis (pwMS) have increased comorbid disease (CMD) risk. Most previous studies have not considered overall CMD burden.OBJECTIVE: To describe lifetime CMD burden among pwMS.METHODS: PwMS identified using Swedish registers between 1968 and 2012 (n = 25,476) were matched by sex, age, and county of residence with general-population comparators (n = 251,170). Prevalence, prevalence ratios (PRs), survival functions, and hazard ratios by MS status, age, and time period compared seven CMD: autoimmune, cardiovascular, depression, diabetes, respiratory, renal, and seizures.RESULTS: The magnitude of the PRs for each CMD and age group decreased across time, with higher PRs in earlier time periods. Before 1990, younger age groups had higher PRs, and after 1990, older age groups had higher PRs. Male pwMS had higher burden compared with females. Overall, renal, respiratory, and seizures had the highest PRs. Before 2001, 50% of pwMS received a first/additional CMD diagnosis 20 years prior to people without MS, which reduced to 4 years after 2001. PwMS had four times higher rates of first/additional diagnoses in earlier time periods, which reduced to less than two times higher in recent time periods compared to people without MS.CONCLUSION: Swedish pwMS have increased CMD burden compared with the general population, but this has reduced over time.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Multiple sclerosis
- Sweden
- burden
- chronic disease
- cohort
- comorbidity
- prevalence
- registries
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- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Smith, Kelsi A.
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Burkill, Sarah
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Hiyoshi, Ayako, ...
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Olsson, Tomas
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Bahmanyar, Shahr ...
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Wormser, David
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Geissbühler, Yvo ...
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Moore, Alan
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Kharat, Vineetku ...
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Montgomery, Scot ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Geriatrik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Multiple Scleros ...
- Av lärosätet
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Örebro universitet
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Stockholms universitet
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Karolinska Institutet