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  • Nilsson, Erik,1975-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,School of Medical Sciences, Örebro University, 70182 Örebro, Sweden. (författare)

Pregnancy Associated Plasma Protein-A as a Cardiovascular Risk Marker in Patients with Stable Coronary Heart Disease During 10 Years Follow-Up-A CLARICOR Trial Sub-Study

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-01-18
  • MDPI,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-80677
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-80677URI
  • https://doi.org/10.3390/jcm9010265DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:du-31734URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-403679URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143056686URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:Copenhagen Trial Unit, Centre for Clinical Intervention Research  Danish Heart Foundation  01-1-5-21-22894 99-2-5-103-22773 99-1-5-87-22712 97-2-5-70-22537Copenhagen Hospital Corporation  Det Frie Forskningsrad (DFF) 9702122 22-00-0261The 1991 Pharmacy Foundation  HPN/ld/71-97Copenhagen Trial Unit 
  • Elevated pregnancy-associated plasma protein A (PAPP-A) is associated with mortality in acute coronary syndromes. Few studies have assessed PAPP-A in stable coronary artery disease (CAD) and results are conflicting. We assessed the 10-year prognostic relevance of PAPP-A levels in stable CAD. The CLARICOR trial was a randomized controlled clinical trial including outpatients with stable CAD, randomized to clarithromycin versus placebo. The placebo group constituted our discovery cohort (n = 1.996) and the clarithromycin group the replication cohort (n = 1.975). The composite primary outcome was first occurrence of cardiovascular event or death. In the discovery cohort, incidence rates (IR) for the composite outcome were higher in those with elevated PAPP-A (IR 12.72, 95% Confidence Interval (CI) 11.0-14.7 events/100 years) compared to lower PAPP-A (IR 8.78, 8.25-9.34), with comparable results in the replication cohort. Elevated PAPP-A was associated with increased risk of the composite outcome in both cohorts (discovery Hazard Ratio (HR) 1.45, 95% CI 1.24-1.70; replication HR 1.29, 95% CI 1.10-1.52). In models adjusted for established risk factors, these trends were attenuated. Elevated PAPP-A was associated with higher all-cause mortality in both cohorts. We conclude that elevated PAPP-A levels are associated with increased long-term mortality in stable CAD, but do not improve long-term prediction of death or cardiovascular events when added to established predictors.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Kastrup, JensDepartment of Cardiology, Rigshospitalet University of Copenhagen, 2100 Copenhagen, Denmark. (författare)
  • Sajadieh, AhmadDepartment of Cardiology, Copenhagen University Hospital of Bispebjerg and Frederiksberg, 2000 Frederiksberg, Denmark. (författare)
  • Jensen, Gorm BojeDepartment of Cardiology, Hvidovre Hospital University of Copenhagen, 2650 Hvidovre, Denmark. (författare)
  • Kjøller, ErikDepartment of Cardiology S, Herlev Hospital University of Copenhagen, Herlev, Denmark; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark,Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark. (författare)
  • Kolmos, Hans JørnDepartment of Clinical Microbiology, Odense University Hospital, 5000 Odense, Denmark. (författare)
  • Wuopio, JonasDepartment of Medicine, Mora County Hospital, 79251 Mora, Sweden. (författare)
  • Nowak, ChristophKarolinska Institutet (författare)
  • Larsson, AndersKarolinska Institutet,Uppsala universitet,Klinisk kemi(Swepub:uu)andlarss (författare)
  • Jakobsen, Janus ChristianCopenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Cardiology, Holbæk Hospital, Holbæk, Denmark,Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark. (författare)
  • Winkel, PerCopenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark. (författare)
  • Gluud, ChristianCopenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark. (författare)
  • Iversen, Kasper K.Department of Cardiology S, Herlev Hospital University of Copenhagen, 2730 Herlev, Denmark. (författare)
  • Ärnlöv, Johan,1970-Karolinska Institutet,Högskolan Dalarna,Medicinsk vetenskap,Division for Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 14183 Huddinge, Sweden.(Swepub:du)jan (författare)
  • Carlsson, Axel C.Division for Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 14183 Huddinge, Sweden. (författare)
  • Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Clinical Medicine: MDPI9:12077-0383

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