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Legumain is upregul...
Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages
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- Lunde, Ngoc Nguyen (author)
- Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway
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- Gregersen, Ida (author)
- Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
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- Ueland, Thor (author)
- Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; K. G. Jebsen Thrombosis Research and Expertise Center, University of Tromsø, Tromsø, Norway,UiT The Arctic University of Norway, Tromsø
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- Shetelig, Christian (author)
- Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevål, Oslo, Norway; Department of Cardiology, Oslo University Hospital Ullevål, Oslo, Norway
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- Holm, Sverre (author)
- Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway
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- Kong, Xiang Yi (author)
- Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
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- Michelsen, Annika E. (author)
- Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
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- Otterdal, Kari (author)
- Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway
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- Yndestad, Arne (author)
- Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
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- Broch, Kaspar (author)
- Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway; KG Jebsen Center for Cardiac Research, University of Oslo, Oslo, Norway and Center for Heart Failure Research, Oslo University Hospital, Oslo, Norway,Norwegian Radium Hospital
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- Gullestad, Lars (author)
- Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway; KG Jebsen Center for Cardiac Research, University of Oslo, Oslo, Norway and Center for Heart Failure Research, Oslo University Hospital, Oslo, Norway,Norwegian Radium Hospital
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- Nyman, Tuula A. (author)
- Proteomics Core Facility, Department of Immunology, Institute of Clinical Medicine, University of Oslo and Rikshospitalet Oslo, Oslo, Norway
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- Bendz, Bjorn (author)
- Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway,Norwegian Radium Hospital
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- Eritsland, Jan (author)
- Oslo Univ Hosp Ulleval, Dept Cardiol, Oslo, Norway.,Oslo university hospital
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- Hoffmann, Pavel (author)
- Section of Interventional Cardiology, Oslo University Hospital Ullevål, Oslo, Norway
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- Skagen, Karolina (author)
- Department of Neurology, Oslo University Hospital Rikshospitalet, Oslo, Norway,Norwegian Radium Hospital
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- Gonçalves, Isabel (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups,Skåne University Hospital
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- Nilsson, Jan (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups
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- Grenegård, Magnus, 1963- (author)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper
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- Poreba, Marcin (author)
- Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wroclaw, Poland,Wrocław University of Science and Technology
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- Drag, Marcin (author)
- Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wroclaw, Poland,Wrocław University of Science and Technology
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- Seljeflot, Ingebjorg (author)
- Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevål, Oslo, Norway; Department of Cardiology, Oslo University Hospital Ullevål, Oslo, Norway
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- Sporsheim, Bjornar (author)
- Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
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- Espevik, Terje (author)
- Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
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- Skjelland, Mona (author)
- Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Neurology, Oslo University Hospital Rikshospitalet, Oslo, Norway,Norwegian Radium Hospital
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- Johansen, Harald Thidemann (author)
- Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway
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- Solberg, Rigmor (author)
- Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway
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- Aukrust, Pål (author)
- Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; K. G. Jebsen Thrombosis Research and Expertise Center, University of Tromsø, Tromsø, Norway; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway,Norwegian Radium Hospital,UiT The Arctic University of Norway, Tromsø
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- Björkbacka, Harry (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - cellulär metabolism och inflammation,Forskargrupper vid Lunds universitet,Cardiovascular Research - Cellular Metabolism and Inflammation,Lund University Research Groups
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- Andersen, Geir Oystein (author)
- Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevål, Oslo, Norway; Department of Cardiology, Oslo University Hospital Ullevål, Oslo, Norway
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- Halvorsen, Bente (author)
- Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
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(creator_code:org_t)
- Elsevier, 2020
- 2020
- English.
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In: Atherosclerosis. - : Elsevier. - 0021-9150 .- 1879-1484. ; 296, s. 74-82
- Related links:
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https://doi.org/10.1...
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http://www.atheroscl...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Background and aims: We have previously found increased levels of the cysteine protease legumain in plasma and plaques from patients with carotid atherosclerosis. This study further investigated legumain during acute cardiovascular events.Methods: Circulating levels of legumain from patients and legumain released from platelets were assessed by enzyme-linked-immunosorbent assay. Quantitative PCR and immunoblotting were used to study expression, while localization was visualized by immunohistochemistry.Results: In the SUMMIT Malmo cohort (n = 339 with or without type 2 diabetes and/or cardiovascular disease [CVD], and 64 healthy controls), the levels of circulating legumain were associated with the presence of CVD in non-diabetics, with no relation to outcome. In symptomatic carotid plaques and in samples from both coronary and intracerebral thrombi obtained during acute cardiovascular events, legumain was co-localized with macrophages in the same regions as platelets. In vitro, legumain was shown to be present in and released from platelets upon activation. In addition, THP-1 macrophages exposed to releasate from activated platelets showed increased legumain expression. Interestingly, primary peripheral blood mononuclear cells stimulated with recombinant legumain promoted anti-inflammatory responses. Finally, in a STEMI population (POSTEMI; n = 272), patients had significantly higher circulating legumain before and immediately after percutaneous coronary intervention compared with healthy controls (n = 67), and high levels were associated with improved outcome.Conclusions: Our data demonstrate for the first time that legumain is upregulated during acute cardiovascular events and is associated with improved outcome.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Cardiovascular disease
- Legumain
- Macrophage
- Plaque modification
- Platelets
- Protease
- Cardiovascular disease
- Legumain
- Macrophage
- Plaque modification
- Platelets
- Protease
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lunde, Ngoc Nguy ...
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Gregersen, Ida
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Ueland, Thor
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Shetelig, Christ ...
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Holm, Sverre
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Kong, Xiang Yi
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Michelsen, Annik ...
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Otterdal, Kari
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Yndestad, Arne
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Broch, Kaspar
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Gullestad, Lars
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Nyman, Tuula A.
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Bendz, Bjorn
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Eritsland, Jan
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Hoffmann, Pavel
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Skagen, Karolina
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Gonçalves, Isabe ...
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Nilsson, Jan
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Grenegård, Magnu ...
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Poreba, Marcin
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Drag, Marcin
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Seljeflot, Ingeb ...
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Sporsheim, Bjorn ...
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Espevik, Terje
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Skjelland, Mona
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Johansen, Harald ...
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Solberg, Rigmor
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Aukrust, Pål
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Björkbacka, Harr ...
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Andersen, Geir O ...
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Halvorsen, Bente
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Atherosclerosis
- By the university
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Örebro University
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Lund University