id:"swepub:oai:DiVA.org:oru-80965"
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- Hillefors, M.Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden (author)
Prominent binding of the dopamine D3 agonist [3H]PD 128907 in the caudate-putamen of the adult rat
- Article/chapterEnglish1999
Publisher, publication year, extent ...
- Elsevier,1999
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:oru-80965
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-80965URI
- https://doi.org/10.1016/s0006-8993(99)01138-5DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:1938186URI
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- Language:English
- Summary in:English
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Notes
- We have analyzed the binding properties of the selective D3 receptor agonist [3H]PD 128907 in 120 days old rats. In tissue sections, we found high numbers of binding sites for [3H]PD 128907 both in the islands of Calleja and the caudate-putamen (Bmax values being 500 and 1000 fmol/mg protein, respectively). The KD values were higher in the caudate-putamen than in the islands of Calleja. Similar regional differences in Bmax and KD values were observed in membranes from the caudate-putamen and the subcortical limbic region. The distribution of [3H]PD 128907 in adult rats is markedly different from that observed in young rats. Taken together, the present results suggest a prominent presence of D3 receptors in the caudate-putamen of adult, but not young, rats. Hence, these findings may have important physiological, pathophysiological, and clinical implications.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmakologi och toxikologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmacology and Toxicology hsv//eng
- PD 128907
- Dopamine D3 receptor
- Binding affinity
- Basal ganglia
- Caudate–putamen
- Islands of Calleja
Added entries (persons, corporate bodies, meetings, titles ...)
- von Euler, Mia,1967-Karolinska Institutet(Swepub:oru)mavr (author)
- Hedlund, P. B.Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden (author)
- von Euler, G.Karolinska Institutet (author)
- Karolinska InstitutetDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden (creator_code:org_t)
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- In:Brain Research: Elsevier822:1-2, s. 126-1310006-89931872-6240
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