Adult height in patients with childhood-onset inflammatory bowel disease: a nationwide population-based cohort study

Adult height in patients with childhood-onset inflammatory bowel disease : a nationwide population-based cohort study

Funding Agencies:Bengt Ihre Foundation Crown Princess Louisa's Memory Fund
Background: Growth retardation is well described in childhood-onset inflammatory bowel disease (IBD).Aims: To study if childhood-onset IBD is associated with reduced final adult height.Methods: We identified 4201 individuals diagnosed with childhood-onset IBD 1990-2014 (Crohn's disease: n = 1640; ulcerative colitis: n = 2201 and IBD-unclassified = 360) in the Swedish National Patient Register.Results: Patients with IBD attained a lower adult height compared to reference individuals (adjusted mean height difference [AMHD] -0.9 cm [95% CI -1.1 to -0.7]) and to their healthy siblings (AMHD -0.8 cm [-1.0 to -0.6]). Patients with Crohn's disease (CD) were slightly shorter than patients with ulcerative colitis (UC; -1.3 cm vs -0.6 cm). Lower adult height was more often seen in patients with pre-pubertal disease onset (AMHD -1.6 cm [-2.0 to -1.2]), and in patients with a more severe disease course (AMHD -1.9 cm, [-2.4 to -1.4]). Some 5.0% of CD and 4.3% of UC patients were classified as growth retarded vs 2.5% of matched reference individuals (OR 2.42 [95% CI 1.85-3.17] and 1.74 [1.36-2.22] respectively).Conclusion: Patients with childhood-onset IBD on average attain a slightly lower adult height than their healthy peers. Adult height was more reduced in patients with pre-pubertal onset of disease and in those with a more severe disease course.

Malmborg, PetterKarolinska Institutet (författare)
Sachs, Michael C.Karolinska Institutet (författare)
Askling, JohanKarolinska Institutet (författare)
Ekbom, AndersKarolinska Institutet (författare)
Neovius, MartinKarolinska Institutet (författare)
Smedby, Karin E.Karolinska Institutet (författare)
Sävendahl, LarsKarolinska Institutet (författare)
Ludvigsson, Jonas F.,1969-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden; Department of Paediatrics, Örebro University Hospital, Örebro, Sweden(Swepub:oru)jsln (författare)
Olén, OlaKarolinska Institutet (författare)
Karolinska InstitutetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Ingår i:Alimentary Pharmacology and Therapeutics: John Wiley & Sons51:8, s. 789-8000269-28131365-2036

Av författaren/redakt...: Mouratidou, Nata ...; Malmborg, Petter; Sachs, Michael C ...; Askling, Johan; Ekbom, Anders; Neovius, Martin; visa fler...; Smedby, Karin E.; Sävendahl, Lars; Ludvigsson, Jona ...; Olén, Ola; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

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