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  • Hadgu, EndaleDepartment of Biochemistry, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia (författare)

Distribution and characteristics of androgen receptor (AR) in breast cancer among women in Addis Ababa, Ethiopia : A cross sectional study

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-05-06
  • Public Library Science,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-81776
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-81776URI
  • https://doi.org/10.1371/journal.pone.0232519DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:Addis Ababa University, School of Graduate Studies, thematic research group "clinico-epidemiological characterization of breast cancer in Ethiopia"  Armauer Hansen Research Institute (AHRI)  AHRI from Swedish International Developmental Agency (SIDA), Sweden 
  • Evaluation of the role of androgen receptor (AR) in the biology of breast cancer is an emerging area of research. There are compelling evidences that AR expression may be used to further refine breast cancer molecular subtyping with prognostic and therapeutic implications. Many studies indicated co-expression of AR with the hormonal receptors in breast cancer has a favorable prognosis. AR is also investigated by many researchers as a potential therapeutic target in treatment of breast cancer. Studies on the frequency and distribution of AR in breast cancer among Africans is barely available. Given the heightened interest to understand its role in breast cancer, we determined AR expression and assessed its association with clinicopathological parameters among Ethiopian women. In this study, 112 newly diagnosed patient with invasive breast cancer at Tikur Anbessa Specialized Hospital were enrolled. Immunohistochemical assessment of AR, ER, PR, Ki67 and HER2 were performed using tissue microarrays (TMA) constructed from their primary tumor block. Out of the 112 participants, 91 (81%) were positive for AR expression and the remaining 21 participants (19%) were negative for AR expression. Expression of AR in ER+, HER2+ and TNBC cases were 93%, 83% and 48% respectively. Our study reveals AR is expressed in a significant number of breast cancers patients and this may indicate that breast cancers cases in Ethiopia have favorable prognosis and could benefit from progresses in AR targeted treatments. Since AR expression has important consequences on the prognosis and treatment of breast cancer, further studies with an increased number of participants is necessary to confirm our reports.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Seifu, DanielDepartment of Biochemistry, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia (författare)
  • Tigneh, WondemagegnhuDepartment of Oncology, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia (författare)
  • Bokretsion, YonasDepartment of Pathology, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia (författare)
  • Bekele, AbebeDepartment of Surgery, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia (författare)
  • Abebe, MarkosArmauer Hansen research Institute (AHRI), Addis Ababa, Ethiopia (författare)
  • Sollie, ThomasSchool of Medical Sciences, Örebro University, Örebro, Sweden (författare)
  • Karlsson, Christina,1968-Örebro universitet,Institutionen för hälsovetenskaper(Swepub:oru)ckn (författare)
  • Karlsson, Mats G.,1960-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)mskn (författare)
  • Department of Biochemistry, School of Medicine, Addis Ababa University, Addis Ababa, EthiopiaDepartment of Oncology, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:PLOS ONE: Public Library Science15:51932-6203

Internetlänk

Hitta via bibliotek

  • PLOS ONE (Sök värdpublikationen i LIBRIS)

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