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Differences between Arterial and Venous Umbilical Cord Plasma Metabolome and Association with Parity
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- Hartvigsson, Olle, 1991 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, Göteborg, Sweden
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- Barman, Malin, 1983 (författare)
- Karolinska Institutet,Chalmers tekniska högskola,Chalmers University of Technology,Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, Göteborg, Sweden; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Savolainen, Otto, 1982 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Mass Spectrometry Infrastructure, Chalmers University of Technology, Göteborg, Sweden
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- Ross, Alastair, 1976 (författare)
- AgResearch,AgResearch Lincoln,AgResearch, Proteins and Metabolites, Lincoln, New Zealand
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- Sandin, Anna (författare)
- Umeå universitet,Pediatrik
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- Jacobsson, Bo, 1960 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Wold, Agnes E, 1955 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
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- Sandberg, Ann-Sofie, 1951 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, Göteborg, Sweden
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- Brunius, Carl, 1974 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, Göteborg, Sweden
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(creator_code:org_t)
- 2022-02-13
- 2022
- Engelska.
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Ingår i: Metabolites. - : MDPI AG. - 2218-1989 .- 2218-1989. ; 12:2
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https://www.mdpi.com...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Umbilical cord blood is frequently used in health monitoring of the neonate. Results may be affected by the proportion of arterial and venous cord blood, the venous blood coming from the mother to supply oxygen and nutrients to the infant, and the arterial carrying waste products from the fetus. Here, we sampled arterial and venous umbilical cords separately from 48 newly delivered infants and examined plasma metabolomes using GC-MS/MS metabolomics. We investigated differences in metabolomes between arterial and venous blood and their associations with gestational length, birth weight, sex, and whether the baby was the first born or not, as well as maternal age and BMI. Using multilevel random forest analysis, a classification rate of 79% was achieved for arteriovenous differences (p = 0.004). Several monosaccharides had higher concentrations in the arterial cord plasma while amino acids were higher in venous plasma, suggesting that the main differences in the measured arterial and venous plasma metabolomes are related to amino acid and energy metabolism. Venous cord plasma metabolites related to energy metabolism were positively associated with parity (77% classification rate, p = 0.004) while arterial cord plasma metabolites were not. This underlines the importance of defining cord blood type for metabolomic studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Nyckelord
- Metabolomics
- Venous
- Parity
- Arte-rial
- Cord
- Plasma
- Umbilical
- Amino acid
- Metabolism
- Energy
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- ref (ämneskategori)
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Hartvigsson, Oll ...
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Barman, Malin, 1 ...
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Savolainen, Otto ...
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Ross, Alastair, ...
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Sandin, Anna
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Jacobsson, Bo, 1 ...
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Wold, Agnes E, 1 ...
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Sandberg, Ann-So ...
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Brunius, Carl, 1 ...
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Metabolites
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Chalmers tekniska högskola
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Göteborgs universitet
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Umeå universitet
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Karolinska Institutet