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Sökning: WFRF:(D'Onofrio Brian M´.) > (2020-2024) > The intergeneration...

  • O'Reilly, Lauren M.Indiana University, Bloomington IN, USA (författare)

The intergenerational transmission of suicidal behavior : an offspring of siblings study

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-05-30
  • Nature Publishing Group,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-82537
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-82537URI
  • https://doi.org/10.1038/s41398-020-0850-6DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143832409URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:American Foundation for Suicide Prevention SRG-0-029-14Indiana Clinical and Translational Sciences Institute: Networks, Complex System and Health Project Development TeamSwedish Initiative for Research on Microdata in the Social And Medical Sciences (SIMSAM) 340-2013-5867United States Department of Health & Human ServicesNIH National Institute of Mental Health (NIMH) F31MH121039
  • We examined the extent to which genetic factors shared across generations, measured covariates, and environmental factors associated with parental suicidal behavior (suicide attempt or suicide) account for the association between parental and offspring suicidal behavior. We used a Swedish cohort of 2,762,883 offspring born 1973-2001. We conducted two sets of analyses with offspring of half- and full-siblings: (1) quantitative behavior genetic models analyzing maternal suicidal behavior and (2) fixed-effects Cox proportional hazard models analyzing maternal and paternal suicidal behavior. The analyses also adjusted for numerous measured covariates (e.g., parental severe mental illness). Quantitative behavior genetic analyses found that 29.2% (95% confidence interval [CI], 5.29, 53.12%) of the intergenerational association was due to environmental factors associated with exposure to maternal suicidal behavior, with the remainder due to genetic factors. Statistical adjustment for parental behavioral health problems partially attenuated the environmental association; however, the results were no longer statistically significant. Cox hazard models similarly found that offspring were at a 2.74-fold increased risk [95% CI, 2.67, 2.83]) of suicidal behavior if their mothers attempted/died by suicide. After adjustment for familial factors and measured covariates, associations attenuated but remained elevated for offspring of discordant half-siblings (HR, 1.57 [95% CI, 1.45, 1.71]) and full-siblings (HR, 1.62 [95% CI, 1.57, 1.67]). Cox hazard models demonstrated a similar pattern between paternal and offspring suicidal behavior. This study found that the intergenerational transmission of suicidal behavior is largely due to shared genetic factors, as well as factors associated with parental behavioral health problems and environmental factors associated with parental suicidal behavior.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Kuja-Halkola, RalfKarolinska Institutet (författare)
  • Rickert, Martin E.Indiana University, Bloomington IN, USA (författare)
  • Class, Quetzal AUniversity of Illinois, Chicago IL, USA (författare)
  • Larsson, Henrik,1975-Örebro universitet,Institutionen för medicinska vetenskaper,Karolinska Institutet, Solna, Sweden(Swepub:oru)hiln (författare)
  • Lichtenstein, PaulKarolinska Institutet (författare)
  • D'Onofrio, Brian M.Karolinska Institutet (författare)
  • Karolinska InstitutetIndiana University, Bloomington IN, USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Translational Psychiatry: Nature Publishing Group10:12158-3188

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