Sökning: WFRF:(Robertson Claudia) >
Impact of Antithrom...
Impact of Antithrombotic Agents on Radiological Lesion Progression in Acute Traumatic Brain Injury : A CENTER-TBI Propensity-Matched Cohort Analysis
-
- Mathieu, François (författare)
- Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada; Division of Anesthesia, Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom; Department of Clinical Neurosciences, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom
-
- Güting, Helge (författare)
- Institute for Research in Operative Medicine (IFOM), Universität Witten/Herdecke, Witten, Germany
-
- Gravesteijn, Benjamin (författare)
- Department of Public Health, Erasmus MC, Rotterdam, the Netherlands
-
visa fler...
-
- Monteiro, Miguel (författare)
- Biomedical Image Analysis Group, Imperial College London, London, United Kingdom
-
- Glocker, Ben (författare)
- Biomedical Image Analysis Group, Imperial College London, London, United Kingdom
-
- Kornaropoulos, Evgenios N. (författare)
- Division of Anesthesia, Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom
-
- Kamnistas, Konstantinos (författare)
- Biomedical Image Analysis Group, Imperial College London, London, United Kingdom
-
- Robertson, Claudia S. (författare)
- Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA
-
- Levin, Harvey (författare)
- Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas, USA
-
- Whitehouse, Daniel P. (författare)
- Division of Anesthesia, Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom
-
- Das, Tilak (författare)
- Department of Radiology, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom
-
- Lingsma, Hester F. (författare)
- Department of Public Health, Erasmus MC, Rotterdam, the Netherlands
-
- Maegele, Marc (författare)
- Institute for Research in Operative Medicine (IFOM), Universität Witten/Herdecke, Witten, Germany; Department of Traumatology and Orthopedic Surgery, Cologne-Merheim Medical Center, Cologne, Germany
-
- Newcombe, Virginia F. J. (författare)
- Division of Anesthesia, Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom
-
- Menon, David K. (författare)
- Division of Anesthesia, Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom
-
- Brorsson, Camilla (författare)
- Umeå universitet,Anestesiologi och intensivvård
-
- Oresic, Matej, 1967- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper
-
, en Glocker (författare)
-
Koskinen, Lars-Owe D., 1955- (bidragsgivare)
-
visa färre...
-
(creator_code:org_t)
- Mary Ann Liebert, 2020
- 2020
- Engelska.
-
Ingår i: Journal of Neurotrauma. - : Mary Ann Liebert. - 0897-7151 .- 1557-9042. ; 37:19, s. 2069-2080
- Relaterad länk:
-
https://www.reposito...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- An increasing number of elderly patients are being affected by traumatic brain injury (TBI) and a significant proportion are on pre-hospital antithrombotic therapy for cardio- or cerebrovascular indications. We have quantified the impact of antiplatelet/anticoagulant (APAC) agents on radiological lesion progression in acute TBI, using a novel, semi-automated approach to volumetric lesion measurement, and explored the impact of use on clinical outcomes in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. We used a 1:1 propensity-matched cohort design, matching controls to APAC users based on demographics, baseline clinical status, pre-injury comorbidities, and injury severity. Subjects were selected from a pool of patients enrolled in CENTER-TBI with computed tomography (CT) scan at admission and repeated within 7 days of injury. We calculated absolute changes in volume of intraparenchymal, extra-axial, intraventricular, and total intracranial hemorrhage (ICH) between scans, and compared volume of hemorrhagic progression, proportion of patients with significant degree of progression (>25% of initial volume), proportion with new ICH on follow-up CT, as well as clinical course and outcomes. A total of 316 patients were included (158 APAC users; 158 controls). The mean volume of progression was significantly higher in the APAC group for extra-axial (3.1 vs. 1.3 mL, p = 0.01), but not intraparenchymal (3.8 vs. 4.6 mL, p = 0.65), intraventricular (0.2 vs. 0.0 mL, p = 0.79), or total intracranial hemorrhage (ICH; 7.0 vs. 6.0 mL, p = 0.08). More patients had significant hemorrhage growth (54.1 vs. 37.0%, p = 0.003) and delayed ICH (4 of 18 vs. none; p = 0.04) in the APAC group compared with controls, but this was not associated with differences in length of stay (LOS), rates of neurosurgical intervention, mortality or Glasgow Outcome Scale Extended (GOS-E) score at 6 months. Pre-injury use of antithrombotic agents was associated with greater expansion of extra-axial lesions, higher rates of significant hemorrhagic progression, and higher risk of delayed traumatic ICH, but this was not associated with worse clinical course or functional outcomes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Anticoagulant
- antiplatelet
- intracranial hemorrhage
- traumatic brain injury
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Mathieu, Françoi ...
-
Güting, Helge
-
Gravesteijn, Ben ...
-
Monteiro, Miguel
-
Glocker, Ben
-
Kornaropoulos, E ...
-
visa fler...
-
Kamnistas, Konst ...
-
Robertson, Claud ...
-
Levin, Harvey
-
Whitehouse, Dani ...
-
Das, Tilak
-
Lingsma, Hester ...
-
Maegele, Marc
-
Newcombe, Virgin ...
-
Menon, David K.
-
Brorsson, Camill ...
-
Oresic, Matej, 1 ...
-
, en Glocker
-
Koskinen, Lars-O ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Neurologi
- Artiklar i publikationen
-
Journal of Neuro ...
- Av lärosätet
-
Örebro universitet
-
Karolinska Institutet
-
Umeå universitet