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How can an organism...
How can an organism´s life experience affect their descendants? Insights from epigenetic and transgenerational effects of chemical exposure in zebrafish
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- Blanc, Mélanie, 1993- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Keiter, Steffen, docent, 1971- (preses)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Rüegg, Joëlle, professor (preses)
- Uppsala University, Uppsala, Sweden
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- Cousin, Xavier, fil.dr (preses)
- IFREMER, L3AS, UMR MARBEC, Palavas-les-Flots, France; UMR GABI INRA, AgroParisTech, University Paris-Saclay, Jouy-en-Josas, France
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- Scherbak, Nikolai, docent, 1967- (preses)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Skinner, Michael K., professor (opponent)
- Center for Reproductive Biology, School of Biological Sciences, Washington State University, United States
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(creator_code:org_t)
- ISBN 9789175293479
- Örebro : Örebro University, 2020
- Engelska 71 s.
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Serie: Örebro Studies in Environmental Science, 1650-6278 ; 18
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- Environmental pollution causes approx. 10% of human diseases, and some develop in the progeny because of parental exposure. Effects passed on to subsequent generations may be a consequence of genetic mutations, or of inherited changes in epigenetic patterns. Epigenetics is the study of mitotically or meiotically heritable changes in gene function that cannot be explained by changes in the DNA sequence. Several chemicals have been suggested to induce epigenetic dysregulation leading to multigenerational and transgenerational effects, i.e. effects that can be observed in completely unexposed generations. However, mechanisms underlying the inheritance of epigenetic changes and their implication in phenotypic adversities are complex and not well-understood. The overall aim of this thesis was to study adverse effects and underlying molecular changes in several generations of zebrafish after parental exposure to selected industrial chemicals. To this end, molecular (lipidomic, transcriptomic, epigenomic) and behavioral analyses were performed. Zebrafish is an acknowledged model for vertebrates in toxicology and biomedicine; as such, the findings can be relevant to many organisms including human. The results from this thesis showed that different types of chemicals, polychlorinated biphenyls, polybromodiphenyl ethers, and permethrin, induced transgenerational effects in concentrations relevant to environmental or human exposures. Impact on anxiety and locomotor activity of zebrafish was observed over several generations. Gene expression and epigenetic (DNA methylation) alterations were partly inherited and suggest stable alteration of specific functions such as glutamatergic/GABAergic neurotransmission and synaptic plasticity. Finally, the findings shed light on experimental limitations and research perspectives, which we expect will contribute to the design of future studies on epigenetically inherited effects of any environmental stress.
Ämnesord
- NATURVETENSKAP -- Biologi -- Annan biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Other Biological Topics (hsv//eng)
Nyckelord
- Neurotoxicity
- behavior
- RNA-Seq
- RRBS
- TEI
- permethrin
- PCBs
- PBDEs
- coumarin 47
Publikations- och innehållstyp
- vet (ämneskategori)
- dok (ämneskategori)
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Blanc, Mélanie, ...
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Keiter, Steffen, ...
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Rüegg, Joëlle, p ...
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Cousin, Xavier, ...
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Scherbak, Nikola ...
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Skinner, Michael ...
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