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Inflammatory functi...
Inflammatory functional iron deficiency common in myelofibrosis, contributes to anaemia and impairs quality of life. From the Nordic MPN study Group
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- Birgegård, Gunnar, 1944- (author)
- Uppsala universitet,Hematologi,Uppsala Univ, Sweden
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- Samuelsson, Jan (author)
- Department of Hematology, University Hospital Linköping, Linköping, Sweden,Univ Hosp Linkoping, Dept Hematol, Linkoping, Sweden,Region Östergötland, Hematologiska kliniken US
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- Ahlstrand, Erik, 1974- (author)
- Region Örebro län,Örebro universitet, Institutionen för medicinska vetenskaper,Orebro Univ, Fac Med & Hlth, Dept Med, Orebro, Sweden
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- Ejerblad, Elisabeth (author)
- Uppsala universitet,Hematologi,Uppsala Univ, Sweden
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- Enevold, Christian (author)
- Institute for Inflammation Research, Copenhagen University Hospital, Copenhagen, Denmark,Copenhagen Univ Hosp, Inst Inflammat Res, Copenhagen, Denmark
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- Ghanima, Waleed (author)
- Department of Research, Østfold Hospital, Sarpsborg, Norway,Ostfold Hosp, Dept Res, Sarpsborg, Norway
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- Hasselbalch, Hans (author)
- Department of Hematology, Zealand University Hospital, Roskilde, Denmark,Zealand Univ Hosp, Dept Hematol, Roskilde, Denmark
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- Nielsen, Claus H. (author)
- Department of Hematology, Zealand University Hospital, Roskilde, Denmark
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- Knutsen, Håvar (author)
- Department of Hematology, Ullevål Hospital, Oslo, Norway,Ulleval Hosp, Dept Hematol, Oslo, Norway
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- Pedersen, Ole B. (author)
- Department of Clinical Immunology, Naestved Hospital, Naestved, Denmark,Naestved Hosp, Dept Clin Immunol, Naestved, Denmark
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- Sørensen, Anders (author)
- Institute for Inflammation Research, Copenhagen University Hospital, Copenhagen, Denmark; Department of Hematology, Zealand University Hospital, Roskilde, Denmark,Copenhagen Univ Hosp, Inst Inflammat Res, Copenhagen, Denmark;Zealand Univ Hosp, Dept Hematol, Roskilde, Denmark
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- Andreasson, Björn (author)
- Hematology Section, Specialist Medicine, NU Hospital Group, Uddevalla, Sweden,NU Hosp Grp, Hematol Sect, Specialist Med, Uddevalla, Sweden
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(creator_code:org_t)
- 2019-01
- 2019
- English.
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In: European Journal of Haematology. - : Munksgaard Forlag. - 0902-4441 .- 1600-0609. ; 102:3, s. 235-240
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- OBJECTIVES: The study investigates the hypothesis that inflammation in myelofibrosis (MF) like in myeloma and lymphoma, may disturb iron distribution and contribute to anaemia.METHODS: A cross-sectional study of 80 MF and 23 ET patients was performed.RESULTS: About 35% of anaemic MF patients had functional iron deficiency (FID) with transferrin saturation <20 and normal or elevated S-ferritin (<500 µg/L). In ET, FID was rare. In MF patients with FID, 70.6% were anaemic, vs 29.4% in patients without FID (P = 0.03). Hepcidin was significantly higher in MF patients with anaemia, including transfusion-dependent patients, 50.6 vs 24.4 µg/L (P = 0.01). There was a significant negative correlation between Hb and inflammatory markers in all MF patients: IL-2, IL-6 and TNF-α, (P < 0.01-0.03), LD (P = 0.004) and hepcidin (P = 0.03). These correlations were also seen in the subgroup of anaemic MF patients (Table ). Tsat correlated negatively with CRP (P < 0.001). Symptom burden was heavier in MF patients with FID, and MPN-SAF quality of life scores correlated with IL-6 and CRP.CONCLUSIONS: The inflammatory state of MF disturbs iron turnover, FID is common and contributes to anaemia development and impairment of QoL. Anaemic MF patients should be screened for FID.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Myelofibrosis
- anaemia of inflammation
- cytokines
- functional iron deficiency
Publication and Content Type
- ref (subject category)
- art (subject category)
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Birgegård, Gunna ...
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Samuelsson, Jan
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Ahlstrand, Erik, ...
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Ejerblad, Elisab ...
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Enevold, Christi ...
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Ghanima, Waleed
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Hasselbalch, Han ...
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Nielsen, Claus H ...
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Knutsen, Håvar
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Pedersen, Ole B.
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Sørensen, Anders
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Andreasson, Björ ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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European Journal ...
- By the university
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Örebro University
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Uppsala University
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Linköping University