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A proposed framewor...
A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals
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- Vandenberg, Laura N. (författare)
- Department of Environmental Health Sciences, University of Massachusetts, Amherst, USA,Univ Massachusetts, Amherst Sch Publ Hlth & Hlth Sci, Dept Environm Hlth Sci, Amherst, MA USA.
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- Ågerstrand, Marlene (författare)
- Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi
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- Beronius, Anna (författare)
- Karolinska Institutet
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- Beausoleil, Claire (författare)
- ANSES French Agcy Food Environm & Occupat Hlth Sa, Maisons Alfort, France.
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- Bergman, Åke (författare)
- Karolinska Institutet,Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi,Swedish Toxicology Sciences Research Center, Sweden
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- Bero, Lisa A. (författare)
- University of Sydney, Sydney, Australia,Univ Sydney, Charles Perkins Ctr, Sydney, NSW, Australia.
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- Bornehag, Carl-Gustaf, 1957- (författare)
- Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Icahn Sch Med Mt Sinai, New York, NY USA.
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- Boyer, C. Scott (författare)
- Swedish Toxicology Sciences Research Center, Södertälje, Sweden,Swedish Toxicol Sci Res Ctr, Sodertalje, Sweden.
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- Cooper, Glinda S. (författare)
- US Environmental Protection Agency, Washington, DC, USA
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- Cotgreave, Ian (författare)
- Karolinska Institutet
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- Gee, David (författare)
- Institute of Environment, Health and Societies, Brunel University London, Uxbridge, England,Brunel Univ London, Inst Environm Hlth & Societies, Uxbridge, Middx, England.
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- Grandjean, Philippe (författare)
- Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark,Univ Southern Denmark, Dept Environm Med, Odense, Denmark. Int Agcy Res Canc, Lyon, France. Tech Univ Denmark, Natl Food Inst, Soborg, Denmark.
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- Guyton, Kathryn Z. (författare)
- International Agency for Research on Cancer, Lyon, France
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- Hass, Ulla (författare)
- National Food Institute, Technical University of Denmark, Søborg, Denmark
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- Heindel, Jerrold J. (författare)
- National Institute of Environmental Health Sciences, NC, USA,Natl Inst Environm Hlth Sci, Div Extramural Res & Training, Res Triangle Pk, NC USA.
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- Jobling, Susan (författare)
- Institute of Environment, Health and Societies, Brunel University London, Uxbridge, England,Brunel Univ London, Inst Environm Hlth & Societies, Uxbridge, Middx, England.
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- Kidd, Karen A. (författare)
- Biology Department and Canadian Rivers Institute, University of New Brunswick, Saint John, Canada; Canadian Rivers Inst, University of New Brunswick, St John, Canada,Univ New Brunswick, Dept Biol, St John, NB, Canada.;Univ New Brunswick, Canadian Rivers Inst, St John, NB, Canada.
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- Kortenkamp, Andreas (författare)
- Institute of Environment, Health and Societies, Brunel University London, Uxbridge, England,Brunel Univ London, Inst Environm Hlth & Societies, Uxbridge, Middx, England.
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- Macleod, Malcolm R. (författare)
- Centre for Clinical Brain Sciences, University of Edinburgh, Scotland,Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland.
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- Martin, Olwenn V. (författare)
- Institute of Environment, Health and Societies, Brunel University London, Uxbridge, England,Brunel Univ London, Inst Environm Hlth & Societies, Uxbridge, Middx, England.
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- Norinder, Ulf, 1956- (författare)
- Karolinska Institutet
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- Scheringer, Martin (författare)
- Institute for Chemical and Bioengineering, ETH Zürich, Zürich, Switzerland,ETH, Inst Chem & Bioengn, Zurich, Switzerland.
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- Thayer, Kristina A. (författare)
- Department of Health and Human Services, National Institute of Environmental Health Sciences, NC, USA,Natl Inst Environm Hlth Sci, Dept Hlth & Human Serv, Div Natl Toxicol Program, NIH, Res Triangle Pk, NC USA.
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- Toppari, Jorma (författare)
- University of Turku, Turku University Hospital, Turku, Finland,Univ Turku, Turku Univ Hosp, Turku, Finland.
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- Whaley, Paul (författare)
- Lancaster Environment Centre, Lancaster University, Lancaster, England,Univ Lancaster, Lancaster Environm Ctr, Lancaster, England.
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- Woodruff, Tracey J. (författare)
- Program on Reproductive Health and the Environment, University of California, San Francisco, USA,Univ Calif San Francisco, Sch Med, Program Reprod Hlth & Environm, Oakland, CA USA.
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- Rudén, Christina (författare)
- Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi
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Department of Environmental Health Sciences, University of Massachusetts, Amherst, USA Univ Massachusetts, Amherst Sch Publ Hlth & Hlth Sci, Dept Environm Hlth Sci, Amherst, MA USA (creator_code:org_t)
- 2016-07-14
- 2016
- Engelska.
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Ingår i: Environmental Health. - London : BioMed Central (BMC). - 1476-069X. ; 15:1
- Relaterad länk:
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https://doi.org/10.1...
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https://ehjournal.bi...
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https://kau.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: The issue of endocrine disrupting chemicals (EDCs) is receiving wide attention from both the scientific and regulatory communities. Recent analyses of the EDC literature have been criticized for failing to use transparent and objective approaches to draw conclusions about the strength of evidence linking EDC exposures to adverse health or environmental outcomes. Systematic review methodologies are ideal for addressing this issue as they provide transparent and consistent approaches to study selection and evaluation. Objective methods are needed for integrating the multiple streams of evidence (epidemiology, wildlife, laboratory animal, in vitro, and in silico data) that are relevant in assessing EDCs.Methods: We have developed a framework for the systematic review and integrated assessment (SYRINA) of EDC studies. The framework was designed for use with the International Program on Chemical Safety (IPCS) and World Health Organization (WHO) definition of an EDC, which requires appraisal of evidence regarding 1) association between exposure and an adverse effect, 2) association between exposure and endocrine disrupting activity, and 3) a plausible link between the adverse effect and the endocrine disrupting activity.Results: Building from existing methodologies for evaluating and synthesizing evidence, the SYRINA framework includes seven steps: 1) Formulate the problem; 2) Develop the review protocol; 3) Identify relevant evidence; 4) Evaluate evidence from individual studies; 5) Summarize and evaluate each stream of evidence; 6) Integrate evidence across all streams; 7) Draw conclusions, make recommendations, and evaluate uncertainties. The proposed method is tailored to the IPCS/WHO definition of an EDC but offers flexibility for use in the context of other definitions of EDCs.Conclusions: When using the SYRINA framework, the overall objective is to provide the evidence base needed to support decision making, including any action to avoid/minimise potential adverse effects of exposures. This framework allows for the evaluation and synthesis of evidence from multiple evidence streams. Finally, a decision regarding regulatory action is not only dependent on the strength of evidence, but also the consequences of action/inaction, e.g. limited or weak evidence may be sufficient to justify action if consequences are serious or irreversible.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Endocrine disrupting chemicals
- Systematic review
- Study evaluation
- Strength of evidence
- Weight of evidence
- Adverse effect
- Endocrine disrupting activity
- Evidence integration
- Epidemiology
- In vivo
- Public Health Science
- Folkhälsovetenskap
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Vandenberg, Laur ...
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Ågerstrand, Marl ...
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Beronius, Anna
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Beausoleil, Clai ...
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Bergman, Åke
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Bero, Lisa A.
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visa fler...
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Bornehag, Carl-G ...
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Boyer, C. Scott
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Cooper, Glinda S ...
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Cotgreave, Ian
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Gee, David
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Grandjean, Phili ...
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Guyton, Kathryn ...
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Hass, Ulla
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Heindel, Jerrold ...
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Jobling, Susan
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Kidd, Karen A.
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Kortenkamp, Andr ...
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Macleod, Malcolm ...
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Martin, Olwenn V ...
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Norinder, Ulf, 1 ...
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Scheringer, Mart ...
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Thayer, Kristina ...
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Toppari, Jorma
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Whaley, Paul
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Woodruff, Tracey ...
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Rudén, Christina
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och Folkhälsovetensk ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Geovetenskap och ...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Hälsovetenskap
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och Arbetsmedicin oc ...
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Environmental He ...
- Av lärosätet
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Örebro universitet
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Karlstads universitet
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Stockholms universitet
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Karolinska Institutet