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Exposure to endocrine-disrupting chemicals in the USA : a population-based disease burden and cost analysis

Attina, Teresa M. (författare)
Department of Pediatrics, New York University School of Medicine, New York, USA
Hauser, Russ (författare)
Department of Environmental Health, Harvard School of Public Health, Boston, USA
Sathyanarayana, Sheela (författare)
Seattle Children's Research Institute, Seattle, USA
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Hunt, Patricia A. (författare)
School of Molecular Biosciences, Washington State University, Pullman, USA
Bourguignon, Jean-Pierre (författare)
Paediatric Endocrinology, Université de Liège, Liège, Belgium
Myers, John P. (författare)
Environmental Health Sciences, Charlottesville, USA
DiGangi, Joseph (författare)
International Persistent Organic Pollutant Elimination Network, Gothenburg, Sweden
Zoeller, R. Thomas, 1952- (författare)
Department of Biology, University of Massachusetts, Amherst, USA
Trasande, Leonardo (författare)
Department of Pediatrics, New York University School of Medicine, New York, USA; Department of Environmental Medicine, New York University School of Medicine, New York, USA; Department of Population Health, New York University School of Medicine, New York, USA; New York University Wagner School of Public Service, New York, USA; NYU Steinhardt School of Culture, Education and Human Development, Department of Nutrition, Food and Public Health, New York, USA; NYU College of Global Public Health, New York, USA
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 (creator_code:org_t)
Elsevier, 2016
2016
Engelska.
Ingår i: The Lancet Diabetes and Endocrinology. - : Elsevier. - 2213-8587 .- 2213-8595. ; 4:12, s. 996-1003
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • BACKGROUND: Endocrine-disrupting chemicals (EDCs) contribute to disease and dysfunction and incur high associated costs (>1% of the gross domestic product [GDP] in the European Union). Exposure to EDCs varies widely between the USA and Europe because of differences in regulations and, therefore, we aimed to quantify disease burdens and related economic costs to allow comparison.METHODS: We used existing models for assessing epidemiological and toxicological studies to reach consensus on probabilities of causation for 15 exposure-response relations between substances and disorders. We used Monte Carlo methods to produce realistic probability ranges for costs across the exposure-response relation, taking into account uncertainties. Estimates were made based on population and costs in the USA in 2010. Costs for the European Union were converted to US$ (€1=$1·33).FINDINGS: The disease costs of EDCs were much higher in the USA than in Europe ($340 billion [2·33% of GDP] vs $217 billion [1·28%]). The difference was driven mainly by intelligence quotient (IQ) points loss and intellectual disability due to polybrominated diphenyl ethers (11 million IQ points lost and 43 000 cases costing $266 billion in the USA vs 873 000 IQ points lost and 3290 cases costing $12·6 billion in the European Union). Accounting for probability of causation, in the European Union, organophosphate pesticides were the largest contributor to costs associated with EDC exposure ($121 billion), whereas in the USA costs due to pesticides were much lower ($42 billion).INTERPRETATION: EDC exposure in the USA contributes to disease and dysfunction, with annual costs taking up more than 2% of the GDP. Differences from the European Union suggest the need for improved screening for chemical disruption to endocrine systems and proactive prevention.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
NATURVETENSKAP  -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
NATURAL SCIENCES  -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)

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Enviromental Science
Miljövetenskap

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