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Adverse Reproductiv...
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Kassotis, Christopher D.Nicholas School of Environment, Duke University, Durham, USA
(author)
Adverse Reproductive and Developmental Health Outcomes Following Prenatal Exposure to a Hydraulic Fracturing Chemical Mixture in Female C57Bl/6 Mice
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-07-05
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Oxford University Press,2016
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Numbers
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LIBRIS-ID:oai:DiVA.org:oru-83776
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-83776URI
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https://doi.org/10.1210/en.2016-1242DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agency:University of Missouri Research CouncilScience To Achieve Results Fellowship Assistance Agreement - United States Environmental Protection Agency, Grant Number: FP-91747101
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Unconventional oil and gas operations using hydraulic fracturing can contaminate surface and groundwater with endocrine-disrupting chemicals. We have previously shown that 23 of 24 commonly used hydraulic fracturing chemicals can activate or inhibit the estrogen, androgen, glucocorticoid, progesterone, and/or thyroid receptors in a human endometrial cancer cell reporter gene assay and that mixtures can behave synergistically, additively, or antagonistically on these receptors. In the current study, pregnant female C57Bl/6 dams were exposed to a mixture of 23 commonly used unconventional oil and gas chemicals at approximately 3, 30, 300, and 3000 μg/kg·d, flutamide at 50 mg/kg·d, or a 0.2% ethanol control vehicle via their drinking water from gestational day 11 through birth. This prenatal exposure to oil and gas operation chemicals suppressed pituitary hormone concentrations across experimental groups (prolactin, LH, FSH, and others), increased body weights, altered uterine and ovary weights, increased heart weights and collagen deposition, disrupted folliculogenesis, and other adverse health effects. This work suggests potential adverse developmental and reproductive health outcomes in humans and animals exposed to these oil and gas operation chemicals, with adverse outcomes observed even in the lowest dose group tested, equivalent to concentrations reported in drinking water sources. These endpoints suggest potential impacts on fertility, as previously observed in the male siblings, which require careful assessment in future studies.
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Bromfield, John J.Department of Animal Sciences, University of Florida, Gainesville, USA; D. H. Barron Reproductive and Perinatal Biology Research Program, University of Florida, Gainesville, USA
(author)
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Klemp, Kara C.Department of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, USA
(author)
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Meng, Chun-XiaDepartment of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, USA
(author)
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Wolfe, AndrewDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, USA
(author)
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Zoeller, R. Thomas,1952-Biology Department, University of Massachusetts, Amherst, USA(Swepub:oru)tzr
(author)
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Balise, Victoria D.Department of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, USA; Division of Biological Sciences, University of Missouri, Columbia, USA
(author)
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Isiguzo, Chiamaka J.Department of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, USA
(author)
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Tillitt, Donald E.Columbia Environmental Research Center, United States Geological Survey, Columbia, USA
(author)
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Nagel, Susan C.Department of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, USA; Division of Biological Sciences, University of Missouri, Columbia, USA
(author)
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Nicholas School of Environment, Duke University, Durham, USADepartment of Animal Sciences, University of Florida, Gainesville, USA; D. H. Barron Reproductive and Perinatal Biology Research Program, University of Florida, Gainesville, USA
(creator_code:org_t)
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In:Endocrinology: Oxford University Press157:9, s. 3469-34810013-72271945-7170
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Örebro University