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Scientific principl...
Scientific principles for the identification of endocrine-disrupting chemicals : a consensus statement
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- Solecki, Roland (author)
- Federal Institute for Risk Assessment, Berlin, Germany
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- Kortenkamp, Andreas (author)
- Institute of Environment, Health and Societies, Brunel University, London, England
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- Bergman, Åke (author)
- Karolinska Institutet
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- Chahoud, Ibrahim (author)
- Charité, Berlin, Germany
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- Degen, Gisela H. (author)
- Karolinska Institutet
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- Dietrich, Daniel (author)
- Universität Konstanz, Konstanz, Germany
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- Greim, Helmut (author)
- TU München, München, Germany
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- Håkansson, Helen (author)
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Hass, Ulla (author)
- Technical University of Denmark, DTU, Søborg, Denmark
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- Husoy, Trine (author)
- Norwegian Institute of Public Health, Oslo, Norway
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- Jacobs, Miriam (author)
- Public Health England, Chilton, England
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- Jobling, Susan (author)
- Institute of Environment, Health and Societies, Brunel University, London, England
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- Mantovani, Alberto (author)
- Istituto Superiore di Sanità, Rome, Italy
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- Marx-Stoelting, Philip (author)
- Federal Institute for Risk Assessment, Berlin, Germany
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- Piersma, Aldert (author)
- RIVM, Bilthoven, Netherlands
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- Ritz, Vera (author)
- Federal Institute for Risk Assessment, Berlin, Germany
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- Slama, Remy (author)
- Inserm, CNRS, Grenoble, France; University Grenoble-Alpes, Grenoble, France
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- Stahlmann, Ralf (author)
- Charité, Berlin, Germany
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- van den Berg, Martin (author)
- Institute of Risk Assessment Studies (IRAS), Utrecht University, Utrecht, Netherlands
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- Zoeller, R. Thomas, 1952- (author)
- University of Massachusetts, Amherst, USA
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- Boobis, Alan R. (author)
- Imperial College London, London, England
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(creator_code:org_t)
- 2016-10-06
- 2017
- English.
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In: Archives of Toxicology. - : Springer. - 0340-5761 .- 1432-0738. ; 91:2, s. 1001-1006
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https://doi.org/10.1...
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https://link.springe...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Endocrine disruption is a specific form of toxicity, where natural and/or anthropogenic chemicals, known as "endocrine disruptors" (EDs), trigger adverse health effects by disrupting the endogenous hormone system. There is need to harmonize guidance on the regulation of EDs, but this has been hampered by what appeared as a lack of consensus among scientists. This publication provides summary information about a consensus reached by a group of world-leading scientists that can serve as the basis for the development of ED criteria in relevant EU legislation. Twenty-three international scientists from different disciplines discussed principles and open questions on ED identification as outlined in a draft consensus paper at an expert meeting hosted by the German Federal Institute for Risk Assessment (BfR) in Berlin, Germany on 11-12 April 2016. Participants reached a consensus regarding scientific principles for the identification of EDs. The paper discusses the consensus reached on background, definition of an ED and related concepts, sources of uncertainty, scientific principles important for ED identification, and research needs. It highlights the difficulty in retrospectively reconstructing ED exposure, insufficient range of validated test systems for EDs, and some issues impacting on the evaluation of the risk from EDs, such as non-monotonic dose-response and thresholds, modes of action, and exposure assessment. This report provides the consensus statement on EDs agreed among all participating scientists. The meeting facilitated a productive debate and reduced a number of differences in views. It is expected that the consensus reached will serve as an important basis for the development of regulatory ED criteria.
Subject headings
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Enviromental Science
- Miljövetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Solecki, Roland
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Kortenkamp, Andr ...
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Bergman, Åke
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Chahoud, Ibrahim
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Degen, Gisela H.
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Dietrich, Daniel
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show more...
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Greim, Helmut
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Håkansson, Helen
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Hass, Ulla
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Husoy, Trine
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Jacobs, Miriam
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Jobling, Susan
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Mantovani, Alber ...
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Marx-Stoelting, ...
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Piersma, Aldert
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Ritz, Vera
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Slama, Remy
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Stahlmann, Ralf
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van den Berg, Ma ...
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Zoeller, R. Thom ...
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Boobis, Alan R.
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Earth and Relate ...
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and Environmental Sc ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Archives of Toxi ...
- By the university
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Örebro University
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Karolinska Institutet