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Urinary concentrati...
Urinary concentrations of phthalate biomarkers and weight change among postmenopausal women : a prospective cohort study
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- Díaz Santana, Mary V. (author)
- Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA
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- Hankinson, Susan E. (author)
- Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA
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- Bigelow, Carol (author)
- Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA
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- Sturgeon, Susan R. (author)
- Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA
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- Zoeller, R. Thomas, 1952- (author)
- Biology Department, University of Massachusetts, Amherst, USA
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- Tinker, Lesley (author)
- Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA
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- Manson, Jo Ann E. (author)
- Department of Medicine, Harvard Medical School, Boston, USA; Harvard T.H. Chan School of Public Health, Boston, USA
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- Calafat, Antonia M. (author)
- Division of Laboratory Sciences, National Center for Environmental Health, Atlanta, USA
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- Meliker, Jaymie R. (author)
- Department of Family Population and Preventive Medicine, Stony Brook University, Stony Brook, USA
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- Reeves, Katherine W. (author)
- Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA
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(creator_code:org_t)
- 2019-03-12
- 2019
- English.
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In: Environmental Health. - : BioMed Central (BMC). - 1476-069X. ; 18:1
- Related links:
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https://doi.org/10.1...
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https://ehjournal.bi...
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https://urn.kb.se/re...
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Abstract
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- BACKGROUND: Some phthalates are endocrine disrupting chemicals used as plasticizers in consumer products, and have been associated with obesity in cross-sectional studies, yet prospective evaluations of weight change are lacking. Our objective was to evaluate associations between phthalate biomarker concentrations and weight and weight change among postmenopausal women.METHODS: We performed cross-sectional (N = 997) and longitudinal analyses (N = 660) among postmenopausal Women's Health Initiative participants. We measured 13 phthalate metabolites and creatinine in spot urine samples provided at baseline. Participants' weight and height measured at in-person clinic visits at baseline, year 3, and year 6 were used to calculate body mass index (BMI). We fit multivariable multinomial logistic regression models to explore cross-sectional associations between each phthalate biomarker and baseline BMI category. We evaluated longitudinal associations between each biomarker and weight change using mixed effects linear regression models.RESULTS: In cross-sectional analyses, urinary concentrations of some biomarkers were positively associated with obesity prevalence (e.g. sum of di (2-ethylhexyl) phthalate metabolites [ΣDEHP] 4th vs 1st quartile OR = 3.29, 95% CI 1.80-6.03 [p trend< 0.001] vs normal). In longitudinal analyses, positive trends with weight gain between baseline and year 3 were observed for mono-(2-ethyl-5-oxohexyl) phthalate, monoethyl phthalate (MEP), mono-hydroxybutyl phthalate, and mono-hydroxyisobutyl phthalate (e.g. + 2.32 kg [95% CI 0.93-3.72] for 4th vs 1st quartile of MEP; p trend < 0.001). No statistically significant associations were observed between biomarkers and weight gain over 6 years.CONCLUSIONS: Certain phthalates may contribute to short-term weight gain among postmenopausal women.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Endocrine disruption
- Obesity
- Phthalates
- Postmenopause
- Weight change
- Women
- Enviromental Science
- Miljövetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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Díaz Santana, Ma ...
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Hankinson, Susan ...
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Bigelow, Carol
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Sturgeon, Susan ...
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Zoeller, R. Thom ...
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Tinker, Lesley
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Manson, Jo Ann E ...
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Calafat, Antonia ...
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Meliker, Jaymie ...
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Reeves, Katherin ...
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- MEDICAL AND HEALTH SCIENCES
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Örebro University