SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Calafat Antonia M.)
 

Sökning: WFRF:(Calafat Antonia M.) > Urinary concentrati...

  • Díaz Santana, Mary V.Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA (författare)

Urinary concentrations of phthalate biomarkers and weight change among postmenopausal women : a prospective cohort study

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2019-03-12
  • BioMed Central (BMC),2019
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-83800
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-83800URI
  • https://doi.org/10.1186/s12940-019-0458-6DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agency:National Institute of Environmental Health Sciences, Grant Number: R01ES024731, R01ES024731S1National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services, Grant Number: HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, HHSN268201600004C
  • BACKGROUND: Some phthalates are endocrine disrupting chemicals used as plasticizers in consumer products, and have been associated with obesity in cross-sectional studies, yet prospective evaluations of weight change are lacking. Our objective was to evaluate associations between phthalate biomarker concentrations and weight and weight change among postmenopausal women.METHODS: We performed cross-sectional (N = 997) and longitudinal analyses (N = 660) among postmenopausal Women's Health Initiative participants. We measured 13 phthalate metabolites and creatinine in spot urine samples provided at baseline. Participants' weight and height measured at in-person clinic visits at baseline, year 3, and year 6 were used to calculate body mass index (BMI). We fit multivariable multinomial logistic regression models to explore cross-sectional associations between each phthalate biomarker and baseline BMI category. We evaluated longitudinal associations between each biomarker and weight change using mixed effects linear regression models.RESULTS: In cross-sectional analyses, urinary concentrations of some biomarkers were positively associated with obesity prevalence (e.g. sum of di (2-ethylhexyl) phthalate metabolites [ΣDEHP] 4th vs 1st quartile OR = 3.29, 95% CI 1.80-6.03 [p trend< 0.001] vs normal). In longitudinal analyses, positive trends with weight gain between baseline and year 3 were observed for mono-(2-ethyl-5-oxohexyl) phthalate, monoethyl phthalate (MEP), mono-hydroxybutyl phthalate, and mono-hydroxyisobutyl phthalate (e.g. + 2.32 kg [95% CI 0.93-3.72] for 4th vs 1st quartile of MEP; p trend < 0.001). No statistically significant associations were observed between biomarkers and weight gain over 6 years.CONCLUSIONS: Certain phthalates may contribute to short-term weight gain among postmenopausal women.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hankinson, Susan E.Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA (författare)
  • Bigelow, CarolDepartment of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA (författare)
  • Sturgeon, Susan R.Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA (författare)
  • Zoeller, R. Thomas,1952-Biology Department, University of Massachusetts, Amherst, USA(Swepub:oru)tzr (författare)
  • Tinker, LesleyCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA (författare)
  • Manson, Jo Ann E.Department of Medicine, Harvard Medical School, Boston, USA; Harvard T.H. Chan School of Public Health, Boston, USA (författare)
  • Calafat, Antonia M.Division of Laboratory Sciences, National Center for Environmental Health, Atlanta, USA (författare)
  • Meliker, Jaymie R.Department of Family Population and Preventive Medicine, Stony Brook University, Stony Brook, USA (författare)
  • Reeves, Katherine W.Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA (författare)
  • Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USABiology Department, University of Massachusetts, Amherst, USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Environmental Health: BioMed Central (BMC)18:11476-069X

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy