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REACH : study protocol of a randomised trial of rehabilitation very early in congenital hemiplegia
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- Boyd, Roslyn N. (författare)
- Queensland Cerebral Palsy and Rehabilitation Research Centre, The University of Queensland, Brisbane, Australia
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- Ziviani, Jenny (författare)
- Children's Allied Health Research, Children's Health Queensland, Brisbane, Australia; The University of Queensland, Brisbane, Australia
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- Sakzewski, Leanne (författare)
- Queensland Cerebral Palsy and Rehabilitation Research Centre, The University of Queensland, Brisbane, Australia
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- Novak, Iona (författare)
- Cerebral Palsy Alliance, The University of Sydney, Sydney, Australia
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- Badawi, Nadia (författare)
- Cerebral Palsy Alliance, The University of Sydney, Sydney, Australia
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- Pannek, Kerstin (författare)
- The Australian E-Health Research Centre, Health and Biosecurity, CSIRO, Brisbane, Australia
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- Elliott, Catherine (författare)
- School of Occupational Therapy and Social Work, Curtin University, Perth, Australia; Perth Children's Hospital, Perth, Australia
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- Greaves, Susan (författare)
- Royal Children's Hospital, Melbourne, Australia
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- Guzzetta, Andrea (författare)
- IRCCS Stella Maris and The University of Pisa, Pisa, Italy
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- Whittingham, Koa (författare)
- Queensland Cerebral Palsy and Rehabilitation Research Centre, The University of Queensland, Brisbane, Australia
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- Valentine, Jane (författare)
- Perth Children's Hospital, Perth, Australia
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- Morgan, Cathy (författare)
- Cerebral Palsy Alliance, The University of Sydney, Sydney, Australia
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- Wallen, Margaret (författare)
- Cerebral Palsy Alliance, The University of Sydney, Sydney, Australia; School of Allied Health, Australian Catholic University, North Sydney, Australia
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- Eliasson, Ann-Christin, 1950- (författare)
- Karolinska Institutet
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- Findlay, Lisa (författare)
- Children's Allied Health Research, Children's Health Queensland, Brisbane, Australia
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- Ware, Robert (författare)
- Menzies Health Institute Queensland, Griffith University Gold Coast, Nathan, Australia
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- Fiori, Simona (författare)
- IRCCS Stella Maris and The University of Pisa, Pisa, Italy
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- Rose, Stephen (författare)
- CSIRO Mathematical and Information Sciences Biomedical Imaging Group, Australian e-Health Research Centre, Australia
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(creator_code:org_t)
- 2017-09-18
- 2017
- Engelska.
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Ingår i: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 7:9
- Relaterad länk:
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https://doi.org/10.1...
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https://bmjopen.bmj....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: Congenital hemiplegia is the most common form of cerebral palsy (CP). Children with unilateral CP show signs of upper limb asymmetry by 8 months corrected age (ca) but are frequently not referred to therapy until after 12 months ca. This study compares the efficacy of infant-friendly modified constraint-induced movement therapy (Baby mCIMT) to infant friendly bimanual therapy (Baby BIM) on upper limb, cognitive and neuroplasticity outcomes in a multisite randomised comparison trial.METHODS AND ANALYSIS: 150 infants (75 in each group), aged between 3 and 6 months ca, with asymmetric brain injury and clinical signs of upper extremity asymmetry will be recruited. Children will be randomised centrally to receive equal doses of either Baby mCIMT or Baby BIM. Baby mCIMT comprises restraint of the unimpaired hand using a simple restraint (eg, glove, sock), combined with intensive parent implemented practice focusing on active use of the impaired hand in a play-based context. In contrast, Baby BIM promotes active play requiring both hands in a play-based context. Both interventions will be delivered by parents at home with monthly home visits and interim telecommunication support by study therapists. Assessments will be conducted at study entry; at 6, 12 months ca immediately postintervention (primary outcome) and 24 months ca (retention). The primary outcome will be the Mini-Assisting Hand Assessment. Secondary outcomes include the Bayley Scale for Infant and Toddler Development (cognitive and motor domains) and the Hand Assessment of Infants. A subset of children will undertake MRI scans at 24 months ca to evaluate brain lesion severity and brain (re)organisation after intervention.ETHICS AND DISSEMINATION: Full ethical approvals for this study have been obtained from the relevant sites. The findings will be disseminated in peer-reviewed publications.TRIAL REGISTRATION NUMBER: Australian and New Zealand Clinical Trials Registry: ACTRN12615000180516, Pre results.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsterapi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Therapy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Bimanual therapy
- brain injury
- cerebral palsy
- congenital hemiplegia
- constraint induced movement therapy
- early intervention
- infant
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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BMJ Open
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
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Boyd, Roslyn N.
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Ziviani, Jenny
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Sakzewski, Leann ...
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Novak, Iona
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Badawi, Nadia
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Pannek, Kerstin
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Elliott, Catheri ...
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Greaves, Susan
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Guzzetta, Andrea
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Whittingham, Koa
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Valentine, Jane
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Morgan, Cathy
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Wallen, Margaret
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Eliasson, Ann-Ch ...
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Findlay, Lisa
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Ware, Robert
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Fiori, Simona
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Rose, Stephen
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsterapi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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BMJ Open
- Av lärosätet
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Örebro universitet
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Karolinska Institutet