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Familial aggregatio...
Familial aggregation of pure tone hearing thresholds in an aging European population
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- Hendrickx, Jan-Jaap (author)
- University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium; Department of Medical Genetics, University of Antwerp, Antwerp, Belgium; StatUa Statistics Center, University of Antwerp, Antwerp, Belgium; Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium
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- Huyghe, Jeroen R. (author)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
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- Topsakal, Vedat (author)
- University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
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- Demeester, Kelly (author)
- University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
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- Wienker, Thomas F. (author)
- Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
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- Laer, Lut Van (author)
- University of Antwerp, Belgium
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- Eyken, Els Van (author)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
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- Fransen, Erik (author)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium; StatUa Statistics Center, University of Antwerp, Antwerp, Belgium
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- Mäki-Torkko, Elina, 1961- (author)
- Institute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu; and Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland
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- Hannula, Samuli (author)
- Institute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu, Finland,University of Oulu and Oulu University Hospital, Finland
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- Parving, Agnete (author)
- Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland,Bispebjerg Hospital, Copenhagen, Denmark
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- Jensen, Mona (author)
- Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland,Bispebjerg Hospital, Copenhagen, Denmark
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- Tropitzsch, Anke (author)
- Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark,University of Tuebingen, Germany
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- Bonaconsa, Amanda (author)
- Department of Otorhinolaryngology, University of Tubingen, Tubingen, Germany,University Hospital Padova, Italy
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- Mazzoli, Manuela (author)
- Department of Otorhinolaryngology, University of Tubingen, Tubingen, Germany,University Hospital Padova, Italy
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- Espeso, Angeles (author)
- Department of Otosurgery, University Hospital Padova, Padova, Italy,University Hospital of Wales, Cardiff, UK
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- Verbruggen, Katja (author)
- Welsh Hearing Institute, University Hospital of Wales, Cardiff, United Kingdom,University Hospital of Gent, Belgium
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- Huyghe, Joke (author)
- Welsh Hearing Institute, University Hospital of Wales, Cardiff, United Kingdom,University Hospital of Gent, Belgium
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- Huygen, Patrick L. M. (author)
- Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands,Radboud University Nijmegen Medical Centre and Donders Institute for Brain, Cognition and Behaviour, the Netherlands
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- Kremer, Hannie (author)
- Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands; Donders Institute for Brain, Cognition and Behaviour, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, Netherlands,Radboud University Nijmegen Medical Centre, the Netherlands
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- Kunst, Sylvia J. (author)
- Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands,Radboud University Nijmegen Medical Centre, the Netherlands
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- Diaz-Lacava, Amalia N. (author)
- Pharmacoepidemiology in Neurodegenerative Disorders, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
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- Steffens, Michael (author)
- Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
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- Pyykkö, Ilmari (author)
- Department of Otorhinolaryngology, University of Tampere, Tampere, Finland
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- Dhooge, Ingeborg (author)
- Welsh Hearing Institute, University Hospital of Wales, Cardiff, United Kingdom,University Hospital of Gent, Belgium
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- Stephens, Dafydd (author)
- Department of Otosurgery, University Hospital Padova, Padova, Italy,University Hospital of Wales, Cardiff, UK
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- Orzan, Eva (author)
- Audiology and Otolaryngology Unit, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy
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- Pfister, Markus H. F. (author)
- Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark,University of Tuebingen, Germany
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- Bille, Michael (author)
- Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland,Bispebjerg Hospital, Copenhagen, Denmark
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- Sorri, Martti (author)
- Institute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu, Finland,University of Oulu and Oulu University Hospital, Finland
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- Cremers, Cor W. R. J. (author)
- Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands,Radboud University Nijmegen Medical Centre, the Netherlands
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- Camp, Guy Van (author)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
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- de Heyning, Paul Van (author)
- University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2013
- 2013
- English.
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In: Otology and Neurotology. - : Lippincott Williams & Wilkins. - 1531-7129 .- 1537-4505. ; 34:5, s. 838-844
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- OBJECTIVE: To investigate the familial correlations and intraclass correlation of age-related hearing impairment (ARHI) in specific frequencies. In addition, heritability estimates were calculated.STUDY DESIGN: Multicenter survey in 8 European centers.SUBJECTS: One hundred ninety-eight families consisting of 952 family members, screened by otologic examination and structured interviews. Subjects with general conditions, known to affect hearing thresholds or known otologic cause were excluded from the study.RESULTS: We detected familial correlation coefficients of 0.36, 0.37, 0.36, and 0.30 for 0.25, 0.5, 1, and 2 kHz, respectively, and correlation coefficients of 0.20 and 0.18 for 4 and 8 kHz, respectively. Variance components analyses showed that the proportion of the total variance attributable to family differences was between 0.32 and 0.40 for 0.25, 0.5, 1, and 2 kHz and below 0.20 for 4 and 8 kHz. When testing for homogeneity between sib pair types, we observed a larger familial correlation between female than male subjects. Heritability estimates ranged between 0.79 and 0.36 across the frequencies.DISCUSSION: Our results indicate that there is a substantial shared familial effect in ARHI. We found that familial aggregation of ARHI is markedly higher in the low frequencies and that there is a trend toward higher familial aggregation in female compared with male subjects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hendrickx, Jan-J ...
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Huyghe, Jeroen R ...
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Topsakal, Vedat
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Demeester, Kelly
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Wienker, Thomas ...
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Laer, Lut Van
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show more...
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Eyken, Els Van
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Fransen, Erik
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Mäki-Torkko, Eli ...
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Hannula, Samuli
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Parving, Agnete
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Jensen, Mona
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Tropitzsch, Anke
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Bonaconsa, Amand ...
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Mazzoli, Manuela
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Espeso, Angeles
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Verbruggen, Katj ...
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Huyghe, Joke
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Huygen, Patrick ...
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Kremer, Hannie
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Kunst, Sylvia J.
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Diaz-Lacava, Ama ...
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Steffens, Michae ...
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Pyykkö, Ilmari
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Dhooge, Ingeborg
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Stephens, Dafydd
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Orzan, Eva
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Pfister, Markus ...
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Bille, Michael
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Sorri, Martti
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Cremers, Cor W. ...
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Camp, Guy Van
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de Heyning, Paul ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Otorhinolaryngol ...
- Articles in the publication
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Otology and Neur ...
- By the university
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Örebro University
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Linköping University