SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Siljander Heli)
 

Sökning: WFRF:(Siljander Heli) > Prenatal exposure t...

Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes

McGlinchey, Aidan J, 1984- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper
Sinioja, Tim, 1983- (författare)
Örebro universitet,Institutionen för naturvetenskap och teknik
Lamichhane, Santosh (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
visa fler...
Sen, Partho (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
Bodin, Johanna (författare)
Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway
Siljander, Heli (författare)
Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Dickens, Alex M. (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
Geng, Dawei (författare)
School of Science and Technology, Örebro University, Örebro, Sweden
Carlsson, Cecilia (författare)
School of Science and Technology, Örebro University, Örebro, Sweden
Duberg, Daniel, 1985- (författare)
Örebro universitet,Institutionen för naturvetenskap och teknik
Ilonen, Jorma (författare)
Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland; Department of Clinical Microbiology, Turku University Hospital, Turku, Finland
Virtanen, Suvi M. (författare)
Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland; Tampere University Hospital, Research, Development and Innovation Center, Tampere, Finland; Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland
Dirven, Hubert (författare)
Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway
Berntsen, Hanne Friis (författare)
Norwegian University of Life Sciences, Oslo, Norway; National Institute of Occupational Health, Oslo, Norway
Zimmer, Karin (författare)
Tampere University Hospital, Research, Development and Innovation Center, Tampere, Finland
Nygaard, Unni C. (författare)
Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway
Oresic, Matej, 1967- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
Knip, Mikael (författare)
Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland; Tampere University Hospital, Research, Development and Innovation Center, Tampere, Finland; Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland
Hyötyläinen, Tuulia, 1971- (författare)
Örebro universitet,Institutionen för naturvetenskap och teknik
visa färre...
 (creator_code:org_t)
Elsevier, 2020
2020
Engelska.
Ingår i: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 143
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid and immune-related markers of T1D risk in children. In a mother-infant cohort (264 dyads), high PFAS exposure during pregnancy associated with decreased cord serum phospholipids and progression to T1D-associated islet autoantibodies in the offspring. This PFAS-lipid association appears exacerbated by increased human leukocyte antigen-conferred risk of T1D in infants. Exposure to a single PFAS compound or a mixture of organic pollutants in non-obese diabetic mice resulted in a lipid profile characterized by a similar decrease in phospholipids, a marked increase of lithocholic acid, and accelerated insulitis. Our findings suggest that PFAS exposure during pregnancy contributes to risk and pathogenesis of T1D in offspring.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)

Nyckelord

Bile acids
Lipidomics
Mass spectrometry
PFAS
Type 1 diabetes

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy