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Prenatal exposure t...
Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes
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- McGlinchey, Aidan J, 1984- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Sinioja, Tim, 1983- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Lamichhane, Santosh (author)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
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- Sen, Partho (author)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
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- Bodin, Johanna (author)
- Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway
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- Siljander, Heli (author)
- Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
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- Dickens, Alex M. (author)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
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- Geng, Dawei (author)
- School of Science and Technology, Örebro University, Örebro, Sweden
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- Carlsson, Cecilia (author)
- School of Science and Technology, Örebro University, Örebro, Sweden
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- Duberg, Daniel, 1985- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Ilonen, Jorma (author)
- Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland; Department of Clinical Microbiology, Turku University Hospital, Turku, Finland
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- Virtanen, Suvi M. (author)
- Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland; Tampere University Hospital, Research, Development and Innovation Center, Tampere, Finland; Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland
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- Dirven, Hubert (author)
- Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway
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- Berntsen, Hanne Friis (author)
- Norwegian University of Life Sciences, Oslo, Norway; National Institute of Occupational Health, Oslo, Norway
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- Zimmer, Karin (author)
- Tampere University Hospital, Research, Development and Innovation Center, Tampere, Finland
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- Nygaard, Unni C. (author)
- Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway
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- Oresic, Matej, 1967- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
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- Knip, Mikael (author)
- Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland; Tampere University Hospital, Research, Development and Innovation Center, Tampere, Finland; Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland
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- Hyötyläinen, Tuulia, 1971- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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(creator_code:org_t)
- Elsevier, 2020
- 2020
- English.
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In: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 143
- Related links:
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https://doi.org/10.1...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid and immune-related markers of T1D risk in children. In a mother-infant cohort (264 dyads), high PFAS exposure during pregnancy associated with decreased cord serum phospholipids and progression to T1D-associated islet autoantibodies in the offspring. This PFAS-lipid association appears exacerbated by increased human leukocyte antigen-conferred risk of T1D in infants. Exposure to a single PFAS compound or a mixture of organic pollutants in non-obese diabetic mice resulted in a lipid profile characterized by a similar decrease in phospholipids, a marked increase of lithocholic acid, and accelerated insulitis. Our findings suggest that PFAS exposure during pregnancy contributes to risk and pathogenesis of T1D in offspring.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- Bile acids
- Lipidomics
- Mass spectrometry
- PFAS
- Type 1 diabetes
Publication and Content Type
- ref (subject category)
- art (subject category)
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McGlinchey, Aida ...
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Sinioja, Tim, 19 ...
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Lamichhane, Sant ...
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Sen, Partho
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Bodin, Johanna
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Siljander, Heli
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Dickens, Alex M.
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Geng, Dawei
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Carlsson, Cecili ...
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Duberg, Daniel, ...
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Ilonen, Jorma
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Virtanen, Suvi M ...
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Dirven, Hubert
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Berntsen, Hanne ...
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Zimmer, Karin
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Nygaard, Unni C.
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Oresic, Matej, 1 ...
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Knip, Mikael
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Hyötyläinen, Tuu ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
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Environment Inte ...
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Örebro University