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Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids

Möller, Steffen (författare)
Rostock University Medical Center, Institute for Biostatistics and Informatics in Medicine and Aging Research, IBIMA, Rostock, Germany
Saul, Nadine (författare)
Humboldt-University of Berlin, Institute of Biology, Berlin, Germany
Cohen, Alan A. (författare)
Department of Family Medicine, University of Sherbrooke, Sherbrooke, Canada
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Köhling, Rüdiger (författare)
Rostock University Medical Center, Oscar-Langendorff-Institute for Physiology, Rostock, Germany
Sender, Sina (författare)
Rostock University Medical Center, Department of Hematology, Oncology and Palliative Medicine, Rostock, Germany
Murua Escobar, Hugo (författare)
Rostock University Medical Center, Department of Hematology, Oncology and Palliative Medicine, Rostock, Germany
Junghanss, Christian (författare)
Rostock University Medical Center, Department of Hematology, Oncology and Palliative Medicine, Rostock, Germany
Cirulli, Francesca (författare)
Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy
Berry, Alessandra (författare)
Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy
Antal, Peter (författare)
Department of Measurement and Information Systems, Budapest University of Technology and Economics, Budapest, Hungary; Abiomics Europe Ltd., Budapest, Hungary
Adler, Priit (författare)
Institute of Computer Science, BIIT research group, University of Tartu, Tartu, Estonia
Vilo, Jaak (författare)
Institute of Computer Science, BIIT research group, University of Tartu, Tartu, Estonia
Boiani, Michele (författare)
Max-Planck Institute for Molecular Biomedicine, Münster, Germany
Jansen, Ludger (författare)
University of Rostock, Institute for Philosophy, Rostock, Germany
Repsilber, Dirk, 1971- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper
Grabe, Hans Jörgen (författare)
University Medicine Greifswald, Clinic and Polyclinic for Psychiatry and Psychotherapy, Greifswald, Germany
Struckmann, Stephan (författare)
Rostock University Medical Center, Institute for Biostatistics and Informatics in Medicine and Aging Research, IBIMA, Rostock, Germany; University Medicine Greifswald, Institute for Community Medicine, Greifswald, Germany
Barrantes, Israel (författare)
Rostock University Medical Center, Institute for Biostatistics and Informatics in Medicine and Aging Research, IBIMA, Rostock, Germany
Hamed, Mohamed (författare)
Rostock University Medical Center, Institute for Biostatistics and Informatics in Medicine and Aging Research, IBIMA, Rostock, Germany
Wouters, Brecht (författare)
KU Leuven, Department of Biology, Leuven, Belgium
Schoofs, Liliane (författare)
KU Leuven, Department of Biology, Leuven, Belgium
Luyten, Walter (författare)
KU Leuven, Department of Biology, Leuven, Belgium
Fuellen, Georg (författare)
Rostock University Medical Center, Institute for Biostatistics and Informatics in Medicine and Aging Research, IBIMA, Rostock, Germany
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 (creator_code:org_t)
2020-07-07
2020
Engelska.
Ingår i: Aging. - : Impact Journals LLC. - 1945-4589 .- 1945-4589. ; 12:13, s. 12534-12581
Relaterad länk:
https://doi.org/10.1...
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https://doi.org/10.1...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
Stäng  
  • The molecular basis of aging and of aging-associated diseases is being unraveled at an increasing pace. An extended healthspan, and not merely an extension of lifespan, has become the aim of medical practice. Here, we define health based on the absence of diseases and dysfunctions. Based on an extensive review of the literature, in particular for humans and C. elegans, we compile a list of features of health and of the genes associated with them. These genes may or may not be associated with survival/lifespan. In turn, survival/lifespan genes that are not known to be directly associated with health are not considered. Clusters of these genes based on molecular interaction data give rise to maps of healthspan pathways for humans and for C. elegans. Overlaying healthspan-related gene expression data onto the healthspan pathway maps, we observe the downregulation of (pro-inflammatory) Notch signaling in humans and of proliferation in C. elegans. We identify transcription, proliferation/biosynthesis and lipids as a common theme on the annotation level, and proliferation-related kinases on the gene/protein level. Our literature-based data corpus, including visualization, should be seen as a pilot investigation of the molecular underpinnings of health in two different species.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Nyckelord

Gene expression analysis
network biology analysis

Publikations- och innehållstyp

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