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  • Martin, JoannaKarolinska Institutet (author)

Investigating gender-specific effects of familial risk for attention-deficit hyperactivity disorder and other neurodevelopmental disorders in the Swedish population

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-06-18
  • Cambridge University Press,2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-84835
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-84835URI
  • https://doi.org/10.1192/bjo.2020.47DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:144079718URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies:Swedish Research Council through the Swedish Initiative for Research on Microdata in the Social and Medical Sciences (SIMSAM) framework  340-2013-5867European Union (EU) 667302 643051
  • Background: Many psychiatric disorders show gender differences in prevalence. Recent studies suggest that female patients diagnosed with anxiety and depression carry more genetic risks related to attention-deficit hyperactivity disorder (ADHD) compared with affected males.Aims: In this register-based study, we aimed to test whether female patients who received clinical diagnoses of anxiety, depressive, bipolar and eating disorders are at higher familial risk for ADHD and other neurodevelopmental disorders, compared with diagnosed male patients.Method: We analysed data from a record-linkage of several Swedish national registers, including 151 025 sibling pairs from 103 941 unique index individuals diagnosed with anxiety, depressive, bipolar or eating disorders, as well as data from 646 948 cousin pairs. We compared the likelihood of having a relative diagnosed with ADHD/neurodevelopmental disorders in index males and females.Results: Female patients with anxiety disorders were more likely than affected males to have a brother with ADHD (odd ratio (OR) = 1.13, 95% CI 1.05-1.22). Results for broader neurodevelopmental disorders were similar and were driven by ADHD diagnoses. Follow-up analyses revealed similar point estimates for several categories of anxiety disorders, with the strongest effect observed for agoraphobia (OR = 1.64, 95% CI 1.12-2.39). No significant associations were found in individuals with depressive, bipolar or eating disorders, or in cousins.Conclusions: These results provide modest support for the possibility that familial/genetic risks for ADHD may show gender-specific phenotypic expression. Alternatively, there could be gender-specific biases in diagnoses of anxiety and ADHD. These factors could play a small role in the observed gender differences in prevalence of ADHD and anxiety.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Ghirardi, LauraKarolinska Institutet (author)
  • Chen, QiKarolinska Institutet (author)
  • Hartman, Catharina A.Karolinska Institutet (author)
  • Rosenqvist, Mina A.Karolinska Institutet (author)
  • Taylor, Mark J.Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Solna, Sweden (author)
  • Birgegård, AndreasKarolinska Institutet (author)
  • Almqvist, CatarinaDepartment of Medical Epidemiology & Biostatistics, Karolinska Institutet, Solna, Sweden; Pediatric Allergy andPulmonology Unit at Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden (author)
  • Lichtenstein, PaulKarolinska Institutet (author)
  • Larsson, Henrik,1975-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Solna, Sweden(Swepub:oru)hiln (author)
  • Karolinska InstitutetDepartment of Medical Epidemiology & Biostatistics, Karolinska Institutet, Solna, Sweden (creator_code:org_t)

Related titles

  • In:BJPsych Open: Cambridge University Press6:42056-4724

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