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  • Štambuk, JerkoGenos Glycoscience Research Laboratory, Zagreb, Croatia (author)

Global variability of the human IgG glycome

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-08-12
  • Impact Journals LLC,2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-85094
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-85094URI
  • https://doi.org/10.18632/aging.103884DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies:European Structural and Investment Funds CEKOM grant KK.01.2.2.03.0006Croatian National Centre of Research Excellence in Personalized Healthcare KK.01.1.1.01.0010National Natural Science Foundation of China (NSFC) 81573215 81773527 81673247 81370083National Health and Medical Research Council of Australia APP1112767National Natural Science Foundation of China (NSFC) 81561128020National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London 
  • Immunoglobulin G (IgG) is the most abundant serum antibody which structural characteristics and effector functions are modulated through the attachment of various sugar moieties called glycans. Composition of the IgG N-glycome changes with age of an individual and in different diseases. Variability of IgG glycosylation within a population is well studied and is known to be affected by both genetic and environmental factors. However, global inter-population differences in IgG glycosylation have never been properly addressed. Here we present population-specific N-glycosylation patterns of IgG, analyzed in 5 different populations totaling 10,482 IgG glycomes, and of IgG's fragment crystallizable region (Fc), analyzed in 2,579 samples from 27 populations sampled across the world. Country of residence associated with many N-glycan features and the strongest association was with monogalactosylation where it explained 38% of variability. IgG monogalactosylation strongly correlated with the development level of a country, defined by United Nations health and socioeconomic development indicators, and with the expected lifespan. Subjects from developing countries had low levels of IgG galactosylation, characteristic for inflammation and ageing. Our results suggest that citizens of developing countries may be exposed to environmental factors that can cause low-grade chronic inflammation and the apparent increase in biological age.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Nakić, NataliDepartment of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy (author)
  • Vučković, FranoGenos Glycoscience Research Laboratory, Zagreb, Croatia (author)
  • Pučić-Baković, MajaGenos Glycoscience Research Laboratory, Zagreb, Croatia (author)
  • Razdorov, GenadijGenos Glycoscience Research Laboratory, Zagreb, Croatia (author)
  • Trbojević-Akmačić, IrenaGenos Glycoscience Research Laboratory, Zagreb, Croatia (author)
  • Novokmet, MislavGenos Glycoscience Research Laboratory, Zagreb, Croatia (author)
  • Keser, TomaFaculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia (author)
  • Vilaj, MarijaGenos Glycoscience Research Laboratory, Zagreb, Croatia (author)
  • Štambuk, TamaraFaculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia (author)
  • Gudelj, IvanGenos Glycoscience Research Laboratory, Zagreb, Croatia (author)
  • Šimurina, MirnaFaculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia (author)
  • Song, ManshuBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China; School of Medical and Health Sciences, Edith Cowan University, Perth, Australia (author)
  • Wang, HaoBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China; School of Medical and Health Sciences, Edith Cowan University, Perth, Australia (author)
  • Salihović, Marijana PeričićInstitute for Anthropological Research, Zagreb, Croatia (author)
  • Campbell, HarryCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, United Kingdom (author)
  • Rudan, IgorCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, United Kingdom (author)
  • Kolčić, IvanaSchool of Medicine, University of Split, Split, Croatia (author)
  • Eller, Leigh AnneWalter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA (author)
  • McKeigue, PaulCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, United Kingdom (author)
  • Robb, Merlin L.Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA (author)
  • Halfvarson, Jonas,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology(Swepub:oru)jshn (author)
  • Kurtoglu, MetinDepartment of Oncology, Koç University School of Medicine, Istanbul, Turkey (author)
  • Annese, VitoCareggi University Hospital, Florence, Italy (author)
  • Škarić-Jurić, TatjanaInstitute for Anthropological Research, Zagreb, Croatia (author)
  • Molokhia, MariamSchool of Population Health and Environmental Sciences, King's College London, London, United Kingdom (author)
  • Polašek, OzrenSchool of Medicine, University of Split, Split, Croatia (author)
  • Hayward, CarolineMRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom (author)
  • Kibuuka, HannahMakerere University Walter Reed Project, Kampala, Uganda (author)
  • Thaqi, KujtimInstitute of Clinical Biochemistry, Priština, Kosovo (author)
  • Primorac, DraganSt. Catherine Hospital, Zagreb, Croatia (author)
  • Gieger, ChristianHelmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany (author)
  • Nitayaphan, SorachaiArmed Forces Research Institute of Medical Sciences, Bangkok, Thailand (author)
  • Spector, TimDepartment of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom (author)
  • Wang, YouxinBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China; School of Medical and Health Sciences, Edith Cowan University, Perth, Australia (author)
  • Tillin, ThereseInstitute of Cardiovascular Science, Faculty of Population Health Sciences, London, United Kingdom (author)
  • Chaturvedi, NishInstitute of Cardiovascular Science, Faculty of Population Health Sciences, London, United Kingdom (author)
  • Wilson, James F.Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, United Kingdom; MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom (author)
  • Schanfield, MosesDepartment of Forensic Sciences, George Washington University, Washington, USA (author)
  • Filipenko, MaximInstitute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia (author)
  • Wang, WeiBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China; School of Medical and Health Sciences, Edith Cowan University, Perth, Australia (author)
  • Lauc, GordanGenos Glycoscience Research Laboratory, Zagreb, Croatia; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia (author)
  • Genos Glycoscience Research Laboratory, Zagreb, CroatiaDepartment of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy (creator_code:org_t)

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  • In:Aging: Impact Journals LLC12:15, s. 15222-152591945-4589

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