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Enlarged perivascul...
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Granberg, TobiasKarolinska Institutet
(author)
Enlarged perivascular spaces in multiple sclerosis on magnetic resonance imaging : a systematic review and meta-analysis
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-06-13
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Springer,2020
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LIBRIS-ID:oai:DiVA.org:oru-85162
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-85162URI
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https://doi.org/10.1007/s00415-020-09971-5DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:143900258URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
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Funding Agency:Swiss National Science Foundation (SNSF)
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BACKGROUND: Perivascular spaces can become detectable on magnetic resonance imaging (MRI) upon enlargement, referred to as enlarged perivascular spaces (EPVS) or Virchow-Robin spaces. EPVS have been linked to small vessel disease. Some studies have also indicated an association of EPVS to neuroinflammation and/or neurodegeneration. However, there is conflicting evidence with regards to their potential as a clinically relevant imaging biomarker in multiple sclerosis (MS).METHODS: To perform a systematic review and meta-analysis of EPVS as visualized by MRI in MS. Nine out of 299 original studies addressing EPVS in humans using MRI were eligible for the systematic review and meta-analysis including a total of 457 MS patients and 352 control subjects.RESULTS: In MS, EPVS have been associated with cognitive decline, contrast-enhancing MRI lesions, and brain atrophy. Yet, these associations were not consistent between studies. The meta-analysis revealed that MS patients have greater EPVS prevalence (odds ratio = 4.61, 95% CI = [1.84; 11.60], p = 0.001) as well as higher EPVS counts (standardized mean difference [SMD] = 0.46, 95% CI = [0.26; 0.67], p < 0.001) and larger volumes (SMD = 0.88, 95% CI = [0.19; 1.56], p = 0.01) compared to controls.CONCLUSIONS: Available literature suggests a higher EPVS burden in MS patients compared to controls. The association of EPVS to neuroinflammatory or -degenerative pathology in MS remains inconsistent. Thus, there is currently insufficient evidence supporting EPVS as diagnostic and/or prognostic marker in MS. In order to benefit future comparisons of studies, we propose recommendations on EPVS assessment standardization in MS. PROSPERO No: CRD42019133946.
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Moridi, ThomasKarolinska Institutet
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Brand, Judith,1984-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Clinical Epidemiology and Biostatistics(Swepub:oru)jhbd
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Neumann, SusanneDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
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Hlavica, MartinDepartment of Neurosurgery, Inselspital, University of Bern, Bern, Switzerland
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Piehl, FredrikKarolinska Institutet
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Ineichen, Benjamin V.Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden
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Karolinska InstitutetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
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In:Journal of Neurology: Springer267:11, s. 3199-32120340-53541432-1459
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