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Effects of prenatal exposure to five parabens on neonatal thyroid function and birth weight : Evidence from SMBCS study

Li, Wenting (författare)
School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China
Guo, Jianqiu (författare)
School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China
Wu, Chunhua (författare)
School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China
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Zhang, Jiming (författare)
School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China
Zhang, Lei (författare)
School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China
Lv, Shenliang (författare)
School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China
Lu, Dasheng (författare)
Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
Qi, Xiaojuan (författare)
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
Feng, Chao (författare)
Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
Liang, Weijiu (författare)
Changning District Center for Disease Control and Prevention, Shanghai, China
Chang, Xiuli (författare)
School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China
Zhang, Yubin (författare)
School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China
Xu, Hao (författare)
Changning District Center for Disease Control and Prevention, Shanghai, China
Cao, Yang, Associate Professor, 1972- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Clinical Epidemiology and Biostatistics
Wang, Guoquan (författare)
Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
Zhou, Zhijun (författare)
School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China
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 (creator_code:org_t)
Academic Press, 2020
2020
Engelska.
Ingår i: Environmental Research. - : Academic Press. - 0013-9351 .- 1096-0953. ; 188
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • BACKGROUND: Parabens, suspected as endocrine-disrupting chemicals, are nearly ubiquitous in the human body and exposure to these chemicals during pregnancy may disrupt thyroid hormones homeostasis and even affect fetal growth, although the impacts are still unclear.OBJECTIVES: We aimed to estimate associations of maternal urinary paraben concentrations with cord serum thyroid hormones and birth weight.METHODS: A subset of 437 mother-newborn pairs were included from a prospective birth cohort with five parabens quantified in maternal urine and seven thyroid function indicators measured in cord serum samples. Multivariable linear regression models and elastic net regression (ENR) models were applied to explore associations between individual and mixtures of prenatal urinary paraben concentrations and thyroid hormones and birth weight, respectively.RESULTS: Maternal urinary ethyl-paraben (EtP) concentrations were associated with increased cord serum total triiodothyronine levels (TT3) [percent change: 1.51%; 95% confidence interval (CI): 0.20%, 2.74%; p=0.017]. Urinary propyl-paraben (PrP) levels predicted higher thyroid peroxidase antibodies (percent change: 4.19%, 95% CI: 0.20%, 8.44%; p=0.041). Maternal urinary EtP and butyl-paraben (BuP) concentrations were significantly positively associated with birth weight [regression coefficient, (β)=40.9g, 95% CI: 3.99, 76.6; p=0.030; β=62.1g, 95% CI: 8.70, 115; p=0.023, for EtP and BuP, respectively]. In sex-stratified analyses, positive relationship between EtP levels and birth weight was observed in boys. Urinary EtP concentrations predicted higher TT3 levels in cord serum samples, assessing parabens as a chemical mixture with ENR models.CONCLUSIONS: Prenatal exposure to parabens may affect thyroid hormone indicators with increased serum TT3 levels and associate with higher birth weight, especially in boys. The underlying biological mechanisms and effects of prenatal paraben exposures on disruption of thyroid function homeostasis and potential impacts of childhood growth and development needed to be further investigated.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)

Nyckelord

Birth weight
Cord serum
Endocrine-disrupting chemicals
Parabens
Thyroid function

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