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Faecal microbiota s...
Faecal microbiota signatures of IBD and their relation to diagnosis, disease phenotype, inflammation, treatment escalation and anti-TNF response in a European Multicentre Study (IBD-Character)
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- Vatn, S. (författare)
- Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway,Akershus Univ Hosp, Norway; Univ Oslo, Norway
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- Carstens, Adam, 1975- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Department of Internal Medicine, Ersta Hospital, Stockholm, Sweden,Orebro Univ, Sweden; Ersta Hosp, Sweden
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- Kristoffersen, A. B. (författare)
- Genetic Analysis AS, Oslo, Norway,Genet Anal AS, Norway
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- Bergemalm, Daniel, 1977- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology,Orebro Univ, Sweden
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- Olbjorn, C. (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Univ Oslo, Norway
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- Moen, A. E. F. (författare)
- Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Clinical Molecular Biology (EpiGen), Division of Medicine, Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway
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- Tannaes, T. M. (författare)
- Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Clinical Molecular Biology (EpiGen), Division of Medicine, Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway
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- Lindstrøm, J. (författare)
- Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway; Department of Pediatric and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway
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- Detlie, T. E. (författare)
- Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway,Akershus Univ Hosp, Norway; Univ Oslo, Norway
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- Olbjørn, C. (författare)
- Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden
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- Lindqvist, Carl Mårten, 1979- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology,Orebro Univ, Sweden
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- Söderholm, Johan D., 1958- (författare)
- Digestive Diseases Unit, IIS Aragón, Zaragoza, Spain
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- Gomollón, F. (författare)
- Gastrointestinal Unit, Centre for Genomics and Molecular Medicine, Division of Medical and Radiological Sciences, University of Edinburgh, Edinburgh, UK,Univ Edinburgh, Scotland
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- Kalla, R. (författare)
- Translational Gastroenterology Unit, Medical Sciences/Experimental Medicine Division, University of Oxford, Oxford, UK,Univ Oxford, England
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- Satsangi, J. (författare)
- Translational Gastroenterology Unit, Medical Sciences/Experimental Medicine Division, University of Oxford, Oxford, UK,Univ Oxford, England
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- Vatn, M. H. (författare)
- Institute of Clinical Medicine, University of Oslo, Oslo, Norway,Univ Oslo, Norway
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- Jahnsen, J. (författare)
- Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway,Akershus Univ Hosp, Norway; Univ Oslo, Norway,Orebro Univ, Sweden
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- Halfvarson, Jonas, 1970- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology
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- Ricanek, P. (författare)
- Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway,Akershus Univ Hosp, Norway
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Casen, C (författare)
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(creator_code:org_t)
- 2020-08-11
- 2020
- Engelska.
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Ingår i: Scandinavian Journal of Gastroenterology. - : Taylor & Francis. - 0036-5521 .- 1502-7708. ; 55:10, s. 1146-1156
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- Method: We examined faecal samples, using the GA-map (TM) Dysbiosis Test, to associate gut microbiota composition with Crohn's disease (CD) and ulcerative colitis (UC) and to identify markers for future biomarker identification. We conducted a prospective case-control study (EU-ref. no. 305676) in an inception cohort of 324 individuals (64 CD, 84 UC, 116 symptomatic non-IBD controls and 44 healthy controls) across five European centres and examined 54 predetermined bacterial markers. We categorized patients according to the Montreal Classification and calculated the dysbiosis index (DI). Non-parametric tests were used to compare groups and the Bonferroni correction to adjust for multiple comparisons.Results: The fluorescent signals (FSSs) for Firmicutes and Eubacterium hallii were lower in inflammatory bowel disease (IBD) vs. symptomatic controls (p<.05). FSS for Firmicutes, Lachnospiraceae, Eubacterium hallii and Ruminococcus albus/bromii were lower, whereas the signal fo rBacteroides Fragilis was higher in UC vs. symptomatic controls (p<.05). FSS was higher for Bifidobacterium spp., Eubacterium hallii, Actinobacteria and Firmicutes among patients with ulcerative proctitis, compared to extensive colitis (p<.05). In CD, we observed no association with disease location. The DI correlated with faecal-calprotectin in both CD and in UC (p<.001). In terms of treatment escalation and anti-TNF response, differences were observed for some bacterial markers, but none of these associations were statistically significant.Conclusion: Our data reveal that the GA-map (TM) Dysbiosis Test holds the potential to characterize the faecal microbiota composition and to assess the degree of dysbiosis in new-onset IBD. On the other hand, our results cannot demonstrate any proven diagnostic or predictive value of this method to support clinical decision making.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Anti-TNF
- Crohn's disease
- dysbiosis
- faecal microbiota
- inflammatory bowel disease
- prognosis
- ulcerative colitis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Vatn, S.
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Carstens, Adam, ...
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Kristoffersen, A ...
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Bergemalm, Danie ...
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Olbjorn, C.
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Moen, A. E. F.
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visa fler...
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Tannaes, T. M.
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Lindstrøm, J.
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Detlie, T. E.
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Olbjørn, C.
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Lindqvist, Carl ...
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Söderholm, Johan ...
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Gomollón, F.
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Kalla, R.
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Satsangi, J.
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Vatn, M. H.
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Jahnsen, J.
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Halfvarson, Jona ...
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Ricanek, P.
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Casen, C
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
- Artiklar i publikationen
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Scandinavian Jou ...
- Av lärosätet
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Örebro universitet
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Linköpings universitet
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Karolinska Institutet