Upfront Radiotherapy in Patients With Asymptomatic Incurable Rectal Cancer: A Retrospective Cohort Study

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: id:"swepub:oai:DiVA.org:oru-86114" > Upfront Radiotherap...

1 av 1
Föregående post
Nästa post
Till träfflistan

Jonsson, GabrielDepartment of Oncology, Mälarsjukhuset, Eskilstuna, Sweden (författare)

Upfront Radiotherapy in Patients With Asymptomatic Incurable Rectal Cancer : A Retrospective Cohort Study

Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

2020-09-28
International Institute of Anticancer Research,2020
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:oru-86114
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-86114URI
https://doi.org/10.21873/anticanres.14604DOI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

BACKGROUND/AIM: The optimal treatment sequencing for asymptomatic de novo metastatic rectal cancer is unclear. The aim of this study was to investigate the role of upfront radiotherapy, with or without chemotherapy on risk for local complications, in patients with asymptomatic advanced metastatic rectal cancer treated with palliative intention.PATIENTS AND METHODS: All patients with de novo metastatic rectal cancer diagnosed between January 2008 and December 2017 in two healthcare regions in Sweden (Örebro län, Sörmland) were identified and data were extracted from electronic medical records. Patients were divided into 3 groups based on treatment sequence: upfront radiotherapy, upfront chemotherapy, and only palliative surgery.RESULTS: In total, 102 patients were included in the study cohort, 30 patients in upfront radiotherapy group, 54 in upfront chemotherapy, and 18 in only palliative surgery group. Patients with only upfront CT [odds ratio (OR)= 5.10; 95% confidence interval (CI)=1.24-20.91, p=0.024] had a higher risk to suffer from a local complication compared to those who received upfront radiotherapy. Cause-specific Cox regression analysis among patients who received oncological therapy revealed that female patients [cause-specific hazard ratio (csHR)=3.61; 95% confidence interval (CI)=1.67-7.81] and upfront chemotherapy [csHR=1.85; 95% CI=1.11-3.77] were associated with increased cumulative incidence of local complication over time, whereas primary surgery with ostomy or stent with lower risk [csHR=0.45; 95% CI=0.21-0.99].CONCLUSION: Patients who received upfront radiotherapy, with or without chemotherapy, had fewer local complications due to primary tumor compared to patients who only received chemotherapy. This could indicate that radiotherapy to the primary tumor could be discussed with the patients as a first treatment option for asymptomatic metastatic rectal cancer to prevent local complications later during the disease.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
Stage IV rectal cancer
chemotherapy
local complication
radiotherapy

Biuppslag (personer, institutioner, konferenser, titlar ...)

Philipson, LouiseFaculty of Medicine and Health, Örebro University, Örebro, Sweden (författare)
Villman, KennethDepartment of Oncology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (författare)
Valachis, Antonis,1984-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Oncology(Swepub:oru)asvs (författare)
Department of Oncology, Mälarsjukhuset, Eskilstuna, SwedenFaculty of Medicine and Health, Örebro University, Örebro, Sweden (creator_code:org_t)

Sammanhörande titlar

Ingår i:Anticancer Research: International Institute of Anticancer Research40:10, s. 5853-58600250-70051791-7530

Internetlänk

Hitta via bibliotek

Anticancer Research (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Av författaren/redakt...: Jonsson, Gabriel; Philipson, Louis ...; Villman, Kenneth; Valachis, Antoni ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: Anticancer Resea ...

Av lärosätet: Örebro universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se