Cortisol levels in children of parents with a substance use disorder

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Fältnamn	Indikatorer	Metadata
000		04766naa a2200433 4500
001		oai:DiVA.org:oru-86299
003		SwePub
008		201030s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-862992 URI
024	7	a https://doi.org/10.1016/j.psyneuen.2013.03.0212 DOI
040		a (SwePub)oru
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Evans, Brittany E,d 1982-u Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center/Sophia Children’s Hospital, Rotterdam, The Netherlands; Department of Developmental Psychology, VU University Amsterdam, Amsterdam, The Netherlands4 aut0 (Swepub:oru)bes
245	1 0	a Cortisol levels in children of parents with a substance use disorder
264	1	b Pergamon Press,c 2013
338		a print2 rdacarrier
500		a Funding Agency:Netherlands Organization for Health Research and Development 3116.0002
520		a BACKGROUND: Children of parents with a substance use disorder (CPSUDs) are at increased risk for the development of substance use disorders later in life, and therefore may manifest vulnerability markers for these disorders at a higher level than children from the general population. Our aim was to examine hypothalamic-pituitary-adrenal (HPA) axis activity as a potential vulnerability marker in CPSUDs as compared to healthy controls. We further examined whether having experienced more adverse life events (ALEs) accounted for differences in cortisol levels between CPSUDs and controls.METHODS: 83 CPSUDs were matched to 83 controls on the basis of age, sex and socioeconomic status. Salivary cortisol was assessed at four time points during a normal day and at six time points during a psychosocial stress procedure, during which perceived stress was also measured. We implemented piecewise multilevel growth curve modeling to examine group differences in diurnal and stress-evoked cortisol levels.RESULTS: Diurnal cortisol levels of CPSUDs did not differ from those of controls. Only stress-evoked cortisol levels at onset of the experiment were explained by group status, such that CPSUDs exhibited lower cortisol levels at onset of the stress procedure. CPSUDs reported experiencing significantly more ALEs, yet number of ALEs was not related to cortisol levels. CPSUDs furthermore reported less perceived stress than controls at onset of the procedure.CONCLUSIONS: HPA axis dysregulation may be a vulnerability marker for substance use disorders, as CPSUDs show blunted activation in anticipation of stress. These blunted cortisol levels were not the result of having experienced more stressful experiences during their lifetimes, thus might reflect an inborn vulnerability to substance use disorders.
650	7	a SAMHÄLLSVETENSKAPx Psykologix Psykologi0 (SwePub)501012 hsv//swe
650	7	a SOCIAL SCIENCESx Psychologyx Psychology0 (SwePub)501012 hsv//eng
653		a Adverse life events
653		a Cortisol
653		a Diurnal
653		a Endophenotype
653		a HPA
653		a Multilevel growth curve
653		a Stress
653		a Substance use disorder
700	1	a Greaves-Lord, Kirstinu Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center/Sophia Children’s Hospital, Rotterdam, The Netherlands4 aut
700	1	a Euser, Anja Su Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center/Sophia Children’s Hospital, Rotterdam, The Netherlands; Department of Psychology, Erasmus University Rotterdam, Rotterdam, The Netherlands4 aut
700	1	a Franken, Ingmar H Au Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center/Sophia Children’s Hospital, Rotterdam, The Netherlands; Department of Psychology, Erasmus University Rotterdam, Rotterdam, The Netherlands4 aut
700	1	a Huizink, Anja Cu Department of Developmental Psychology, VU University Amsterdam, Amsterdam, The Netherlands4 aut
710	2	a Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center/Sophia Children’s Hospital, Rotterdam, The Netherlands; Department of Developmental Psychology, VU University Amsterdam, Amsterdam, The Netherlandsb Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center/Sophia Children’s Hospital, Rotterdam, The Netherlands4 org
773	0	t Psychoneuroendocrinologyd : Pergamon Pressg 38:10, s. 2109-2120q 38:10<2109-2120x 0306-4530x 1873-3360
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-86299
856	4 8	u https://doi.org/10.1016/j.psyneuen.2013.03.021

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Av författaren/redakt...: Evans, Brittany ...; Greaves-Lord, Ki ...; Euser, Anja S; Franken, Ingmar ...; Huizink, Anja C

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