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The P300 event-rela...
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Euser, Anja SInstitute of Psychology, Erasmus University Rotterdam, The Netherlands; Department of Child and Adolescent Psychiatry, Erasmus Medical Center Rotterdam, The Netherlands
(författare)
The P300 event-related brain potential as a neurobiological endophenotype for substance use disorders : a meta-analytic investigation
- Artikel/kapitelEngelska2012
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Pergamon Press,2012
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LIBRIS-ID:oai:DiVA.org:oru-86309
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-86309URI
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https://doi.org/10.1016/j.neubiorev.2011.09.002DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:for swepub-publicationtype
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Funding Agency:Netherlands Organization for Scientific Research (NWO) ZonMW; 3116.0002
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Endophenotypes are intermediate phenotypes on the putative causal pathway from genotype to phenotype and can aid in discovering the genetic etiology of a disorder. There are currently very few suitable endophenotypes available for substance use disorders (SUD). The amplitude of the P300 event-related brain potential is a possible candidate. The present study determined whether the P300 amplitude fulfils two fundamental criteria for an endophenotype: (1) an association with the disorder (disease marker), and (2) presence in unaffected biological relatives of those who have the disorder (vulnerability marker). For this purpose, two separate meta-analyses were performed. Meta-analysis 1 investigated the P300 amplitude in relation to SUD in 39 studies and Meta-analysis 2 investigated P300 amplitude in relation to a family history (FH+) of SUD in 35 studies. The findings indicate that a reduced P300 amplitude is significantly associated with SUD (d=0.51) and, though to a lesser extent, with a FH+ of SUD (d=0.28). As a disease maker, the association between reduced P300 amplitude and SUD is significantly larger for participants that were exclusively recruited from treatment facilities (d=0.67) than by other methods (i.e., community samples and family studies; d=0.45 and 0.32, respectively), and larger for abstinent SUD patients (d=0.71) than for current substance users (d=0.37). Furthermore, in contrast to FH+ males, a P300 amplitude reduction seems not to be present in FH+ females (d=-0.07). Taken together, these results suggest that P300 amplitude reduction can be both a useful disease and vulnerability marker and is a promising neurobiological endophenotype for SUD, though only in males. Implications and future directions are discussed.
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Arends, Lidia RInstitute of Psychology, Erasmus University Rotterdam, The Netherlands; Department of Biostatistics, Erasmus Medical Center Rotterdam, The Netherlands
(författare)
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Evans, Brittany E,1982-Department of Child and Adolescent Psychiatry, Erasmus Medical Center Rotterdam, The Netherlands; Research Institute of Child Development and Education, University of Amsterdam, Amsterdam, The Netherlands(Swepub:oru)bes
(författare)
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Greaves-Lord, KirstinDepartment of Child and Adolescent Psychiatry, Erasmus Medical Center Rotterdam, The Netherlands
(författare)
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Huizink, Anja CResearch Institute of Child Development and Education, University of Amsterdam, Amsterdam, The Netherlands; Behavioral Science Institute, Radboud University, Nijmegen, The Netherlands; Research Institute for Addiction (IVO), Rotterdam, The Netherlands
(författare)
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Franken, Ingmar H AInstitute of Psychology, Erasmus University Rotterdam, The Netherlands
(författare)
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Institute of Psychology, Erasmus University Rotterdam, The Netherlands; Department of Child and Adolescent Psychiatry, Erasmus Medical Center Rotterdam, The NetherlandsInstitute of Psychology, Erasmus University Rotterdam, The Netherlands; Department of Biostatistics, Erasmus Medical Center Rotterdam, The Netherlands
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Neuroscience and Biobehavioral Reviews: Pergamon Press36:1, s. 572-6030149-76341873-7528
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