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  • Biström, MartinUmeå University,Umeå universitet,Neurovetenskaper,Umea Univ, Sweden (author)

Epstein-Barr virus infection after adolescence and Human herpesvirus 6A as risk factors for multiple sclerosis

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2020-11-22
  • Blackwell Publishing,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-86808
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-86808URI
  • https://doi.org/10.1111/ene.14597DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169075URI
  • https://lup.lub.lu.se/record/ac86843b-795f-4c75-99f4-6afc585f87c5URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145170596URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-171836URI
  • https://gup.ub.gu.se/publication/298343URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies:KAW Foundation  Margaretha af Ugglas Foundation  Horizon 2020 MultipleMS  733161Multiple Sclerosis Society of Canada  EGID 3045
  • Funding Agencies|Swedish Research CouncilSwedish Research Council [2015-02419]; Swedish Brain Foundation; KAW Foundation; Margaretha af Ugglas Foundation; Horizon 2020 MultipleMS [733161]; Multiple Sclerosis Society of Canada [EGID 3045]
  • Background and purpose: Infections with human herpesvirus 6A (HHV-6A) and Epstein–Barr virus (EBV) have been linked to multiple sclerosis (MS) development. For EBV, late infection has been proposed as a risk factor, but serological support is lacking. The objective of this study was to investigate how age affects the EBV and HHV-6A associated risks of developing MS.Methods: In this nested case–control study, Swedish biobanks were accessed to find pre-symptomatically collected blood samples from 670 individuals who later developed relapsing MS and 670 matched controls. A bead-based multiplex assay was used to determine serological response against EBV and HHV-6A. Conditional logistic regression was used to calculate odds ratios and 95% confidence intervals.Results: Seropositivity against EBV exhibited a pattern where associations switched from a decreased risk of developing MS in the group below 20 years of age to an increased risk amongst individuals aged 20–29 and 30–39 years (p for trend 0.020). The age of transition was estimated to be 18.8 years. In contrast, HHV-6A was associated with increased MS risk in all age groups (total cohort odds ratio 2.1, 95% confidence interval 1.6–2.7).Conclusions: This study suggests EBV infection after adolescence and age independent HHV-6A infection as risk factors for MS.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Jons, Daniel,1974Gothenburg University,Göteborgs universitet,University of Gothenburg,Univ Gothenburg, Sweden,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xjdani (author)
  • Engdahl, ElinKarolinska Institute,Karolinska Inst, Sweden; Ctr Mol Med, Sweden (author)
  • Gustafsson, RasmusKarolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden; Ctr Mol Med, Sweden (author)
  • Huang, JesseKarolinska Institute,Karolinska Inst, Sweden; Ctr Mol Med, Sweden (author)
  • Brenner, NicoleInfections and Cancer Epidemiology, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany,German Canc Res Ctr, Germany (author)
  • Butt, JuliaInfections and Cancer Epidemiology, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany,German Canc Res Ctr, Germany (author)
  • Alonso-Magdalena, L.Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund Univ, Sweden; Lund Univ, Sweden(Swepub:lu)med-lua (author)
  • Gunnarsson, Martin,1973-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden(Swepub:oru)mign (author)
  • Vrethem, MagnusLinköpings universitet,Linköping University,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping(Swepub:liu)magvr07 (author)
  • Bender, NoemiInfections and Cancer Epidemiology, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany (author)
  • Waterboer, TimInfections and Cancer Epidemiology, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany,German Canc Res Ctr, Germany (author)
  • Granåsen, Gabriel,1980-Umeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Umea Univ, Sweden(Swepub:umu)galgrn00 (author)
  • Olsson, TomasKarolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden; Ctr Mol Med, Sweden (author)
  • Kockum, IngridKarolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden; Ctr Mol Med, Sweden (author)
  • Andersen, Oluf,1941Gothenburg University,Göteborgs universitet,University of Gothenburg,Univ Gothenburg, Sweden,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xandeo (author)
  • Fogdell-Hahn, AnnaKarolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden; Ctr Mol Med, Sweden (author)
  • Sundström, PeterUmeå University,Umeå universitet,Neurovetenskaper,Umea Univ, Sweden(Swepub:umu)pesu0002 (author)
  • Umeå universitetNeurovetenskaper (creator_code:org_t)

Related titles

  • In:European Journal of Neurology: Blackwell Publishing28:2, s. 579-5861351-51011468-1331

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