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  • Meng, Wen-JianLinköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Sichuan Univ, Peoples R China (författare)

Expressions of miR-302a, miR-105, and miR-888 Play Critical Roles in Pathogenesis, Radiotherapy, and Prognosis on Rectal Cancer Patients : A Study From Rectal Cancer Patients in a Swedish Rectal Cancer Trial of Preoperative Radiotherapy to Big Database Analyses

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-10-06
  • Frontiers,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-87081
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-87081URI
  • https://doi.org/10.3389/fonc.2020.567042DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-171478URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:144967641URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agency:Health Research Council in the South-East of Sweden 1921-B91-08XBC
  • Funding Agencies|Swedish Cancer Foundation; Swedish Research CouncilSwedish Research Council; Health Research Council in the South-East of Sweden [1921-B91-08XBC]
  • Differential expressions and functions of various micoRNAs (miRNAs) have been intensively studied in both colon and rectal cancers. However, the importance of miRNAs on radiotherapy (RT) response and clinical outcome in rectal cancer patients remains unclear. In this study, we used real-time polymerase chain reaction to examine the expressions of miR-302a, miR-105, and miR-888 in normal mucosa and cancer tissue from rectal cancer patients with and without preoperative RT. The biological function of miR-302a, miR-105, and miR-888 expression was further analyzed and identified through the public databases: TCGA (The Cancer Genome Atlas) and GEPIA (Gene Expression Profiling Interactive Analysis). The results showed that the expression of miR-105 in rectal cancer was higher than that in normal mucosa in RT (P = 0.042) and non-RT patients (P = 0.003) and was associated with mucinous histological type (P = 0.004), COX-2 (P = 0.042), and p73 expression (P = 0.030). The expression of miR-302a was shown more frequently in cancers with necrosis (P = 0.033) and with WRAP53 expression (P = 0.015), whereas miR-888 expression occurred more frequently in tumors with protein the expression of survivin (P = 0.015), AEG-1 (astrocyte elevated gene-1) (P = 0.003), and SATB1 (special AT-rich sequence binding protein 1) (P = 0.036). Moreover, TargetScan also predicted AEG-1 and SATB1 as putative targets for miR-888. The miRNA-gene network analysis showed that ABI2 was associated with all the three miRNAs, with lower expression and good diagnostic value in rectal cancers. The TCGA database demonstrated the association of miR-105 expression with high carcinoembryonic antigen level (P = 0.048). RT reduced the expressions of miR-302a, miR-105, and miR-888. Prognostic analysis showed that miR-888 expression was independently associated with worse survival of patients without RT [overall survival, P = 0.001; disease-free survival, P = 0.009]. Analysis of biological function revealed that the protein serine/threonine kinase activity and PI3K-AKT signaling pathway were the most significantly enriched functions and pathways, respectively. Our findings suggest that miR-105 is involved in rectal cancer pathogenesis and miR-888 is associated with prognosis. MiR-302a, miR-105, and miR-888 have potential influence on the pathogenesis, RT, and prognosis of rectal cancer.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Pathak, SurajitLinköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Chettinad Acad Res & Educ, India(Swepub:liu)surpa77 (författare)
  • Xueli, Zhang,1991-Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden(Swepub:oru)zxi (författare)
  • Adell, GunnarLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US(Swepub:liu)gunad10 (författare)
  • Jarlsfelt, IngvarDepartment of Pathology, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden (författare)
  • Holmlund, BirgittaLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US(Swepub:liu)birho30 (författare)
  • Wang, Zi-QiangDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China,Sichuan Univ, Peoples R China (författare)
  • Zhang, Alexander S.Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden,Karolinska Inst, Sweden (författare)
  • Zhang, Hong,1957-Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden,Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China(Swepub:oru)hzg (författare)
  • Zhou, Zong-GuangDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China; State Key Laboratory of Biotherapy and Cancer Center, Institute of Digestive Surgery, West China Hospital, Sichuan University, Chengdu, China (författare)
  • Sun, Xiao-FengLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US(Swepub:liu)xiasu45 (författare)
  • Linköpings universitetInstitutionen för biomedicinska och kliniska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Frontiers in Oncology: Frontiers102234-943X

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