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Impact of an antimi...
Impact of an antimicrobial stewardship programme on antimicrobial utilization and the prevalence of MDR Pseudomonas aeruginosa in an acute care hospital in Qatar
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- Sid Ahmed, Mazen, 1970- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Microbiology Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar,The Life Science Centre-Biology
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- Abdel Hadi, Hamad (författare)
- Departments of Infectious Diseases, Hamad Medical Corporation, Doha, Qatar
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- Abu Jarir, Sulieman (författare)
- Departments of Infectious Diseases, Hamad Medical Corporation, Doha, Qatar
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- Al Khal, Abdul Latif (författare)
- Departments of Infectious Diseases, Hamad Medical Corporation, Doha, Qatar
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- Al-Maslamani, Muna A. (författare)
- Departments of Infectious Diseases, Hamad Medical Corporation, Doha, Qatar
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- Jass, Jana, 1963- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,The Life Science Centre-Biology
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- Ibrahim, Emad Bashi (författare)
- Microbiology Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar; Biomedical Research Center, Qatar University, Doha, Qatar
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- Ziglam, Hisham (författare)
- Departments of Infectious Diseases, Hamad Medical Corporation, Doha, Qatar
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(creator_code:org_t)
- 2020-08-07
- 2020
- Engelska.
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Ingår i: JAC - Antimicrobial Resistance. - : Oxford University Press. - 2632-1823. ; 2:3
- Relaterad länk:
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https://doi.org/10.1...
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: The excessive and inappropriate use of antibiotics is universal across all healthcare facilities. In Qatar there has been a substantial increase in antimicrobial consumption coupled with a significant rise in antimicrobial resistance (AMR). Antimicrobial stewardship programmes (ASPs) have become a standard intervention for effective optimization of antimicrobial prescribing.Methods: A before–after study was conducted in Hamad General Hospital (603 bed acute care hospital): 1 year before implementation of a comprehensive ASP compared with the following 2 years. The ASP included a hospital-wide pre-authorization requirement by infectious diseases physicians for all broad-spectrum antibiotics. Prevalence of MDR Pseudomonas aeruginosa was compared with antimicrobial consumption, calculated as DDD per 1000 patient-days (DDD/1000 PD). Susceptibility was determined using broth microdilution, as per CLSI guidelines. Antibiotic use was restricted through the ASP, as defined in the hospital’s antibiotic policy.Results: A total of 6501 clinical isolates of P. aeruginosa were collected prospectively over 3 years (2014–17). Susceptibility to certain antimicrobials improved after the ASP was implemented in August 2015. The prevalence of MDR P. aeruginosa showed a sustained decrease from 2014 (9%) to 2017 (5.46%) (P"0.019). There was a significant 23.9% reduction in studied antimicrobial consumption following ASP implementation (P"0.008). They early consumption of meropenem significantly decreased from 47.32 to 31.90 DDD/1000 PD (P"0.012), piperacillin/tazobactam from 45.35 to 32.67 DDD/1000 PD (P,0.001) and ciprofloxacin from 9.71 to 5.63 DDD/1000 PD (P"0.015) (from 2014 to 2017).Conclusions: The successful implementation of the ASP led to a significant reduction in rates of MDR P. aeruginosa, pointing towards the efficacy of the ASP in reducing AMR.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
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