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Insights in the reg...
Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears
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- Ebert, Thomas (author)
- Karolinska Institutet
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- Painer, Johanna (author)
- Department of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, Veterinary University Vienna, Vienna, Austria
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- Bergman, Peter (author)
- Karolinska Institutet
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- Qureshi, Abdul Rashid (author)
- Karolinska Institutet
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- Giroud, Sylvain (author)
- Department of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, Veterinary University Vienna, Vienna, Austria
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- Stalder, Gabrielle (author)
- Department of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, Veterinary University Vienna, Vienna, Austria
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- Kublickiene, Karolina (author)
- Karolinska Institutet
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- Göritz, Frank (author)
- Leibniz Institute for Zoo and Wildlife Ecology, Berlin, Germany
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- Vetter, Sebastian (author)
- Department of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, Veterinary University Vienna, Vienna, Austria
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- Bieber, Claudia (author)
- Department of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, Veterinary University Vienna, Vienna, Austria
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- Fröbert, Ole, 1964- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology
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- Arnemo, Jon (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för vilt, fisk och miljö,Department of Wildlife, Fish and Environmental Studies,Inland Norway University of Applied Sciences
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- Zedrosser, Andreas (author)
- Department of Natural Sciences and Environmental Health, University of South-Eastern Norway, Bø i Telemark, Norway; Institute for Wildlife Biology and Game Management, University for Natural Resources and Life Sciences, Vienna, Austria
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- Redtenbacher, Irene (author)
- Four Paws International, Vienna, Austria
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- Shiels, Paul G. (author)
- Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK
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- Johnson, Richard J. (author)
- Division of Renal Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
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- Stenvinkel, Peter (author)
- Karolinska Institutet
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(creator_code:org_t)
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- 2020-11-23
- 2020
- English.
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In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 10:1
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https://doi.org/10.1...
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https://www.nature.c...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Experimental studies suggest involvement of trimethylamine N-oxide (TMAO) in the aetiology of cardiometabolic diseases and chronic kidney disease (CKD), in part via metabolism of ingested food. Using a comparative biomimetic approach, we have investigated circulating levels of the gut metabolites betaine, choline, and TMAO in human CKD, across animal species as well as during hibernation in two animal species. Betaine, choline, and TMAO levels were associated with renal function in humans and differed significantly across animal species. Free-ranging brown bears showed a distinct regulation pattern with an increase in betaine (422%) and choline (18%) levels during hibernation, but exhibited undetectable levels of TMAO. Free-ranging brown bears had higher betaine, lower choline, and undetectable TMAO levels compared to captive brown bears. Endogenously produced betaine may protect bears and garden dormice during the vulnerable hibernating period. Carnivorous eating habits are linked to TMAO levels in the animal kingdom. Captivity may alter the microbiota and cause a subsequent increase of TMAO production. Since free-ranging bears seems to turn on a metabolic switch that shunts choline to generate betaine instead of TMAO, characterisation and understanding of such an adaptive switch could hold clues for novel treatment options in burden of lifestyle diseases, such as CKD.
Subject headings
- NATURVETENSKAP -- Biologi -- Etologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Behavioural Sciences Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Zoologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Zoology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ebert, Thomas
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Painer, Johanna
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Bergman, Peter
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Qureshi, Abdul R ...
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Giroud, Sylvain
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Stalder, Gabriel ...
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Kublickiene, Kar ...
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Göritz, Frank
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Vetter, Sebastia ...
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Bieber, Claudia
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Fröbert, Ole, 19 ...
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Arnemo, Jon
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Zedrosser, Andre ...
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Redtenbacher, Ir ...
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Shiels, Paul G.
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Johnson, Richard ...
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Stenvinkel, Pete ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Behavioural Scie ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Zoology
- Articles in the publication
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Scientific Repor ...
- By the university
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Örebro University
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Karolinska Institutet
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Swedish University of Agricultural Sciences