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  • Ebert, ThomasKarolinska Institutet (författare)

Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-11-23
  • Nature Publishing Group,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-87594
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-87594URI
  • https://doi.org/10.1038/s41598-020-76346-1DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145264210URI
  • https://res.slu.se/id/publ/109855URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:Njurfonden (Swedish Kidney Foundation) Strategic Research Programme in Diabetes at Karolinska Institutet (Swedish Research Council) 2009-1068University of Glasgow  Constant Pharma Ltd  4D Pharma limitedLundbeckfonden R126-2012-12408 R194-2015-1108 R286-2018-367Augustinus Foundation 
  • Experimental studies suggest involvement of trimethylamine N-oxide (TMAO) in the aetiology of cardiometabolic diseases and chronic kidney disease (CKD), in part via metabolism of ingested food. Using a comparative biomimetic approach, we have investigated circulating levels of the gut metabolites betaine, choline, and TMAO in human CKD, across animal species as well as during hibernation in two animal species. Betaine, choline, and TMAO levels were associated with renal function in humans and differed significantly across animal species. Free-ranging brown bears showed a distinct regulation pattern with an increase in betaine (422%) and choline (18%) levels during hibernation, but exhibited undetectable levels of TMAO. Free-ranging brown bears had higher betaine, lower choline, and undetectable TMAO levels compared to captive brown bears. Endogenously produced betaine may protect bears and garden dormice during the vulnerable hibernating period. Carnivorous eating habits are linked to TMAO levels in the animal kingdom. Captivity may alter the microbiota and cause a subsequent increase of TMAO production. Since free-ranging bears seems to turn on a metabolic switch that shunts choline to generate betaine instead of TMAO, characterisation and understanding of such an adaptive switch could hold clues for novel treatment options in burden of lifestyle diseases, such as CKD.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Painer, JohannaDepartment of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, Veterinary University Vienna, Vienna, Austria (författare)
  • Bergman, PeterKarolinska Institutet (författare)
  • Qureshi, Abdul RashidKarolinska Institutet (författare)
  • Giroud, SylvainDepartment of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, Veterinary University Vienna, Vienna, Austria (författare)
  • Stalder, GabrielleDepartment of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, Veterinary University Vienna, Vienna, Austria (författare)
  • Kublickiene, KarolinaKarolinska Institutet (författare)
  • Göritz, FrankLeibniz Institute for Zoo and Wildlife Ecology, Berlin, Germany (författare)
  • Vetter, SebastianDepartment of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, Veterinary University Vienna, Vienna, Austria (författare)
  • Bieber, ClaudiaDepartment of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, Veterinary University Vienna, Vienna, Austria (författare)
  • Fröbert, Ole,1964-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology(Swepub:oru)oft (författare)
  • Arnemo, JonSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för vilt, fisk och miljö,Department of Wildlife, Fish and Environmental Studies,Inland Norway University of Applied Sciences(Swepub:slu)49057 (författare)
  • Zedrosser, AndreasDepartment of Natural Sciences and Environmental Health, University of South-Eastern Norway, Bø i Telemark, Norway; Institute for Wildlife Biology and Game Management, University for Natural Resources and Life Sciences, Vienna, Austria (författare)
  • Redtenbacher, IreneFour Paws International, Vienna, Austria (författare)
  • Shiels, Paul G.Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK (författare)
  • Johnson, Richard J.Division of Renal Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO, USA (författare)
  • Stenvinkel, PeterKarolinska Institutet (författare)
  • Karolinska InstitutetDepartment of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, Veterinary University Vienna, Vienna, Austria (creator_code:org_t)
  • Sveriges lantbruksuniversitet

Sammanhörande titlar

  • Ingår i:Scientific Reports: Nature Publishing Group10:12045-2322

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