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Pre-operative beta-...
Pre-operative beta-blocker therapy does not affect short-term mortality after esophageal resection for cancer
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- Reda, Souheil, 1988- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Division of Upper Gastrointestinal Surgery, Department of Surgery, Örebro University Hospital, Örebro, Swede
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- Ahl, Rebecka, 1987- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Division of Trauma and Emergency Surgery, Department of Surgery, Karolinska University Hospital, Stockholm, Sweden; Division of Surgery, CLINTEC, Karolinska Institutet, Stockholm, Sweden
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- Szabo, Eva, 1973- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Division of Upper Gastrointestinal Surgery, Department of Surgery, Örebro University Hospital, Örebro, Sweden
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- Stenberg, Erik, 1979- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Division of Upper Gastrointestinal Surgery, Department of Surgery, Örebro University Hospital, Örebro, Sweden
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- Forssten, Maximilian Peter, 1996- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Division of Trauma and Emergency Surgery, Department of Surgery, Örebro University Hospital, Örebro, Sweden
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- Sjölin, Gabriel, 1979- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Division of Trauma and Emergency Surgery, Department of Surgery, Örebro University Hospital, Örebro, Sweden
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- Cao, Yang, Associate Professor, 1972- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Clinical Epidemiology and Biostatistics
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- Mohseni, Shahin, 1978- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Division of Trauma and Emergency Surgery, Department of Surgery, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- 2020-12-22
- 2020
- Engelska.
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Ingår i: BMC Surgery. - : BioMed Central. - 1471-2482. ; 20:1
- Relaterad länk:
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https://doi.org/10.1...
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https://bmcsurg.biom...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: It has been postulated that the hyperadrenergic state caused by surgical trauma is associated with worse outcomes and that β-blockade may improve overall outcome by downregulation of adrenergic activity. Esophageal resection is a surgical procedure with substantial risk for postoperative mortality. There is insufficient data to extrapolate the existing association between preoperative β-blockade and postoperative mortality to esophageal cancer surgery. This study assessed whether preoperative β-blocker therapy affects short-term postoperative mortality for patients undergoing esophageal cancer surgery.METHODS: All patients with an esophageal cancer diagnosis that underwent surgical resection with curative intent from 2007 to 2017 were retrospectively identified from the Swedish National Register for Esophagus and Gastric Cancers (NREV). Patients were subdivided into β-blocker exposed and unexposed groups. Propensity score matching was carried out in a 1:1 ratio. The outcome of interest was 90-day postoperative mortality.RESULTS: A total of 1466 patients met inclusion criteria, of whom 35% (n = 513) were on regular preoperative β-blocker therapy. Patients on β-blockers were significantly older, more comorbid and less fit for surgery based on their ASA score. After propensity score matching, 513 matched pairs were available for analysis. No difference in 90-day mortality was detected between β-blocker exposed and unexposed patients (6.0% vs. 6.6%, p = 0.798).CONCLUSION: Preoperative β-blocker therapy is not associated with better short-term survival in patients subjected to curative esophageal tumor resection.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Beta-blocker
- Beta-blocker in surgery
- Esophageal cancer
- Mortality
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Reda, Souheil, 1 ...
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Ahl, Rebecka, 19 ...
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Szabo, Eva, 1973 ...
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Stenberg, Erik, ...
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Forssten, Maximi ...
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Sjölin, Gabriel, ...
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Cao, Yang, Assoc ...
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Mohseni, Shahin, ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
- Artiklar i publikationen
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BMC Surgery
- Av lärosätet
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Örebro universitet
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Karolinska Institutet