Sökning: (WFRF:(Brunner Eric)) srt2:(2020-2023) >
Appetite disinhibit...
Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory
-
- Brunner, Eric J. (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK
-
- Maruyama, Koutatsu (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK; Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan; Laboratory of Community Health and Nutrition, Department of Bioscience, Graduate School of Agriculture, Ehime University, Matsuyama, Japan
-
- Shipley, Martin (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK
-
visa fler...
-
- Cable, Noriko (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK
-
- Iso, Hiroyasu (författare)
- Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan
-
- Hiyoshi, Ayako, 1972- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics
-
- Stallone, Daryth (författare)
- Nutrepol, Merritt Island, FL, USA
-
- Kumari, Meena (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK; Institute for Social and Economic Research, University of Essex, Colchester, UK
-
- Tabak, Adam (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK; Department of Internal Medicine and Ocology, Faculty of Medicine, Semmelweis University, Budapest, Hungary; Department of Public Health, Faculty of Medicine, Semmelweis University, Budapest, Hungary
-
- Singh-Manoux, Archana (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK; Epidemiology of Ageing and Neurodegenerative diseases, Université de Paris, Paris, France
-
- Wilson, John (författare)
- North Devon Medical Education Centre, North Devon District Hospital, Barnstaple, UK
-
- Langenberg, Claudia (författare)
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK
-
- Wareham, Nick (författare)
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK
-
- Boniface, David (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK
-
- Hingorani, Aroon (författare)
- Institute of Cardiovascular Science, University College London, London, UK
-
- Kivimäki, Mika (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK
-
- Llewellyn, Clare (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK
-
visa färre...
-
(creator_code:org_t)
- 2021-01-14
- 2021
- Engelska.
-
Ingår i: International Journal of Obesity. - : Nature Publishing Group. - 0307-0565 .- 1476-5497. ; 45, s. 758-765
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://www.nature.c...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND/OBJECTIVES: The mediating role of eating behaviors in genetic susceptibility to weight gain during mid-adult life is not fully understood. This longitudinal study aims to help us understand contributions of genetic susceptibility and appetite to weight gain.SUBJECTS/METHODS: We followed the body-mass index (BMI) trajectories of 2464 adults from 45 to 65 years of age by measuring weight and height on four occasions at 5-year intervals. Genetic risk of obesity (gene risk score: GRS) was ascertained, comprising 92 BMI-associated single-nucleotide polymorphisms and split at a median (=high and low risk). At the baseline, the Eating Inventory was used to assess appetite-related traits of 'disinhibition', indicative of opportunistic eating or overeating and 'hunger' which is susceptibility to/ability to cope with the sensation of hunger. Roles of the GRS and two appetite-related scores for BMI trajectories were examined using a mixed model adjusted for the cohort effect and sex.RESULTS: Disinhibition was associated with higher BMI (beta = 2.96; 95% CI: 2.66-3.25 kg/m(2)), and accounted for 34% of the genetically-linked BMI difference at age 45. Hunger was also associated with higher BMI (beta = 1.20; 0.82-1.59 kg/m(2)) during mid-life and slightly steeper weight gain, but did not attenuate the effect of disinhibition. CONCLUSIONS: Appetite disinhibition is most likely to be a defining characteristic of genetic susceptibility to obesity. High levels of appetite disinhibition, rather than hunger, may underlie genetic vulnerability to obesogenic environments in two-thirds of the population of European ancestry.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Brunner, Eric J.
-
Maruyama, Koutat ...
-
Shipley, Martin
-
Cable, Noriko
-
Iso, Hiroyasu
-
Hiyoshi, Ayako, ...
-
visa fler...
-
Stallone, Daryth
-
Kumari, Meena
-
Tabak, Adam
-
Singh-Manoux, Ar ...
-
Wilson, John
-
Langenberg, Clau ...
-
Wareham, Nick
-
Boniface, David
-
Hingorani, Aroon
-
Kivimäki, Mika
-
Llewellyn, Clare
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Folkhälsovetensk ...
- Artiklar i publikationen
-
International Jo ...
- Av lärosätet
-
Örebro universitet