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  • Daouacher, Georgios,1978-Department of Urology, Central Hospital of Karlstad, Karlstad, Sweden (author)

Laparoscopic extended pelvic lymph node (LN) dissection as validation of the performance of [(11) C]-acetate positron emission tomography/computer tomography in the detection of LN metastasis in intermediate- and high-risk prostate cancer

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2015-07-20
  • Blackwell Publishing,2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-88720
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-88720URI
  • https://doi.org/10.1111/bju.13202DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-261195URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVES: To evaluate the accuracy of the radiopharmaceutical [(11) C]-acetate combined with positron emission tomography/computer tomography (acetate-PET/CT) in lymph node (LN) staging in newly diagnosed prostate cancer cases. A second aim was to evaluate the potential discriminative properties of acetate-PET/CT in clinical routine.PATIENTS AND METHODS: In a prospective comparative study, from July 2010 to June 2013, 53 men with newly histologically diagnosed intermediate- or high-risk prostate cancer underwent acetate-PET/CT investigation at one regional centre before laparoscopic extended pelvic LN dissection (ePLND) at one referral centre. The sensitivity, specificity and accuracy of acetate-PET/CT were calculated. Comparisons were made between true-positive and false-negative PET/CT cases to identify differences in the clinical parameters: PSA level, Gleason status, lymph metastasis burden and size, calculated risk of LN involvement, and curative treatment decisions.RESULTS: In all, 26 patients had surgically/histologically confirmed LN metastasis (LN+). Acetate-PET/CT was true positive in 10 patients, false positive in one, false negative in 16, and true negative in 26. The individual sensitivity was 38%, specificity 96%, and accuracy 68%. The acetate-PET/CT positive cases had significantly more involved LNs (mean 7.9 vs 2.4, P < 0.001) with larger cancer diameters (14.1 vs 4.9 mm, P = 0.001) and fewer eventually had treatment with curative intent (40% vs 94%, P <0.005), although we lack long-term outcome data.CONCLUSION: Acetate-PET/CT has too low a sensitivity for routine LN staging but the specificity is high. The acetate-PET/CT positive cases have a very high burden of LN spread.

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  • von Below, CatrinUppsala universitet,Radiologi(Swepub:uu)cavon168 (author)
  • Gestblom, CharlottaDepartment of Pathology, Central Hospital of Karlstad, Karlstad, Sweden (author)
  • Ahlström, HåkanUppsala universitet,Radiologi(Swepub:uu)hakanahl (author)
  • Grzegorek, RafaelDepartment of Urology, Central Hospital of Karlstad, Karlstad, Sweden (author)
  • Wassberg, CeciliaUppsala universitet,Radiologi(Swepub:uu)ceciwass (author)
  • Sörensen, JensUppsala universitet,Radiologi(Swepub:uu)jenssore (author)
  • Waldén, MauritzDepartment of Urology, Central Hospital of Karlstad, Karlstad, SwedenDepartment of Urology, Central Hospital of Karlstad, Karlstad, Sweden (author)
  • Department of Urology, Central Hospital of Karlstad, Karlstad, SwedenRadiologi (creator_code:org_t)

Related titles

  • In:BJU International: Blackwell Publishing118:1, s. 77-831464-40961464-410X

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