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Are the Morphologic...
Are the Morphological Indices of the Vertebrobasilar System Heritable? A Twin Study Based on 3D Reconstructed Models
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- Szalontai, Laszlo (författare)
- Medical Imaging Centre, Semmelweis University, Budapest, Hungary; Oncologic Imaging Diagnostic Center, Department of Radiology, National Institute of Oncology, Budapest, Hungary
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- Jokkel, Zsofia (författare)
- Medical Imaging Centre, Semmelweis University, Budapest, Hungary
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- Horvath, Tamas (författare)
- HeartBit, Budapest, Hungary
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- Piroska, Marton (författare)
- Medical Imaging Centre, Semmelweis University, Budapest, Hungary
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- Forgo, Bianka, 1992- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Radiology
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- Olah, Csaba (författare)
- Department of Neurosurgery, University of Debrecen, Debrecen, Hungary
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- Kostyal, Laszlo (författare)
- Department of Radiology, Borsod County University Teaching Hospital, Miskolc, Hungary
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- Tarnoki, David L. (författare)
- Medical Imaging Centre, Semmelweis University, Budapest, Hungary; Oncologic Imaging Diagnostic Center, Department of Radiology, National Institute of Oncology, Budapest, Hungary
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- Tarnoki, Adam D. (författare)
- Medical Imaging Centre, Semmelweis University, Budapest, Hungary; Oncologic Imaging Diagnostic Center, Department of Radiology, National Institute of Oncology, Budapest, Hungary
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(creator_code:org_t)
- 2021-02-01
- 2021
- Engelska.
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Ingår i: Medicina (Kaunas). - : MDPI. - 1010-660X .- 1648-9144. ; 57:2
- Relaterad länk:
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https://doi.org/10.3...
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background and Objectives: The asymmetrical vertebral artery (VA) flow and diameter are common findings, which can result in an asymmetrical blood flow in the basilar artery (BA), leading to bending of the artery over time. This study investigated whether the variation of the different vertebrobasilar morphological indices that influence flow characteristics might be inherited.Materials and Methods: We analyzed 200 cerebral magnetic resonance imaging (MRI) scans of healthy Caucasian twins (100 pairs) who underwent time-of-flight MRI. From the scans, we reconstructed the 3D mesh of the posterior circulation from the start of the V4 segment to the basilar tip and subsequently analyzed the morphology of the vertebrobasilar system. The phenotypic covariances of the different morphological parameters were decomposed into heritability (A), shared (C), and unshared (E) environmental effects.Results: 39% of the twins had left dominant VA, while 32.5% had right dominant. In addition, 28.5% were classified as equal. The vertebral artery V4 segment diameter, curvature, and tortuosity were mainly influenced by shared (C) and unshared (E) environmental factors. A moderate heritability was found for the BA length (A: 63%; 95% CI: 45.7-75.2%; E: 37%; 95% CI: 24.8-54.3%) and volume (A: 60.1%; 95% CI: 42.4-73.2%; E: 39.9%; 95% CI: 26.8-57.6%), while the torsion of both arteries showed no heritability and were only influenced by the unshared environment.Conclusions: The length and volume of the BA show a moderate genetical influence. However, most of the measured morphological indices were influenced by shared and unshared factors, which highlight the role of the ever-changing hemodynamic influences shaping the geometry of the vertebrobasilar system.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- 3D vascular reconstruction
- basilar artery curve
- heritability
- twin study
- vertebral artery dominance
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Szalontai, Laszl ...
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Jokkel, Zsofia
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Horvath, Tamas
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Piroska, Marton
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Forgo, Bianka, 1 ...
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Olah, Csaba
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Kostyal, Laszlo
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Tarnoki, David L ...
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Tarnoki, Adam D.
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Örebro universitet