Pregnancy outcomes in women with immunoglobulin A nephropathy: a nationwide population-based cohort study

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Jarrick, Simon,1977-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Pediatrics, Örebro University Hospital, Örebro, Sweden (author)

Pregnancy outcomes in women with immunoglobulin A nephropathy : a nationwide population-based cohort study

Article/chapterEnglish2021

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2021-03-08
Springer,2021
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LIBRIS-ID:oai:DiVA.org:oru-90325
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-90325URI
https://doi.org/10.1007/s40620-021-00979-2DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:146209268URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Funding Agencies:Research Committee of Örebro County Council Janssen corporation
BACKGROUND: Immunoglobulin A nephropathy (IgAN) incidence peaks in childbearing age. Data on pregnancy outcomes in women with IgAN are limited.METHODS: We performed a register-based cohort study in a nationwide cohort of women with biopsy-verified IgAN in Sweden, comparing 327 pregnancies in 208 women with biopsy-verified IgAN and 1060 pregnancies in a matched reference population of 622 women without IgAN, with secondary comparisons with sisters to IgAN women. Adverse pregnancy outcomes, identified by way of the Swedish Medical Birth Register, were compared through multivariable logistic regression and presented as adjusted odds ratios (aORs). Main outcome was preterm birth (< 37 weeks). Secondary outcomes were preeclampsia, small for gestational age (SGA), low 5-min Apgar score (< 7), fetal or infant loss, cesarean section, and gestational diabetes.RESULTS: We found that IgAN was associated with an increased risk of preterm birth (13.1% vs 5.6%; aOR = 2.69; 95% confidence interval [CI] = 1.52-4.77), preeclampsia (13.8% vs 4.2%; aOR = 4.29; 95%CI = 2.42-7.62), SGA birth (16.0% vs 11.1%; aOR = 1.84; 95%CI = 1.17-2.88), and cesarean section (23.9% vs 16.2%; aOR = 1.74, 95%CI = 1.14-2.65). Absolute risks were low for intrauterine (0.6%) or neonatal (0%) death and for low 5-min Apgar score (1.5%), and did not differ from the reference population. Sibling comparisons suggested increased risks of preterm birth, preeclampsia, and SGA in IgAN, but not of cesarean section.CONCLUSION: We conclude that although most women with IgAN will have a favorable pregnancy outcome, they are at higher risk of preterm birth, preeclampsia and SGA. Intensified supervision during pregnancy is warranted.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
Epidemiology
Glomerulonephritis
IgA nephropathy
Pregnancy
Prognosis

Added entries (persons, corporate bodies, meetings, titles ...)

Lundberg, SigridKarolinska Institutet (author)
Stephansson, OlofKarolinska Institutet (author)
Symreng, AdinaClinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden (author)
Bottai, MatteoKarolinska Institutet (author)
Höijer, JonasDivision of Biostatisitcs, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (author)
Ludvigsson, Jonas F.,1969-Karolinska Institutet(Swepub:oru)jsln (author)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

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In:JN. Journal of Nephrology: Springer34:5, s. 1591-15981121-84281724-6059

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

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By the university: Örebro University; Karolinska Institutet

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