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Dietary Gluten Inta...
Dietary Gluten Intake Is Not Associated With Risk of Inflammatory Bowel Disease in US Adults Without Celiac Disease
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- Lopes, Emily W. (author)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston MA, USA
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- Lebwohl, Benjamin (author)
- Celiac Disease Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
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- Burke, Kristin E. (author)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston MA, USA
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- Ivey, Kerry L. (author)
- Department of Nutrition and Dietetics, College of Nursing and Health Sciences, Flinders University, Adelaide, Australia; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; South Australian Health and Medical Research Institute, Infection and Immunity Theme, School of Medicine, Flinders University, Adelaide, SA, Australia
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- Ananthakrishnan, Ashwin N. (author)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Clinical and Translation Epidemiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
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- Lochhead, Paul (author)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston MA, USA
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- Richter, James M. (author)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston MA, USA
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- Ludvigsson, Jonas F., 1969- (author)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden
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- Willett, Walter C. (author)
- Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
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- Chan, Andrew T. (author)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Clinical and Translation Epidemiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
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- Khalili, Hamed (author)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Clinical and Translation Epidemiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Clinical Gastroenterology and Hepatology. - : Elsevier. - 1542-3565 .- 1542-7714. ; 20:2, s. 303-313.e6
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND & AIMS: Diet is thought to play a role in the development of inflammatory bowel disease (IBD), though the relationship between gluten intake and risk of IBD has not been explored. The aim of this study was to determine the relationship between gluten intake and risk of incident Crohn's disease (CD) and ulcerative colitis (UC).METHODS: We performed a prospective cohort study of 208,280 US participants from the Nurses' Health Study (NHS; 1986-2016), NHSII (1991-2017), and Health Professionals Follow-up Study (1986-2016) who did not have IBD at baseline or celiac disease, and who completed semi-quantitative food frequency questionnaires. We used Cox proportional hazards modeling to estimate the risk of IBD according to quintiles of cumulative average energy-adjusted dietary gluten intake over follow-up period.RESULTS: We documented 337 CD cases and 447 UC cases over 5,115,265 person-years of follow-up evaluation. Dietary gluten intake was not associated with risk of IBD. Compared with participants in the lowest quintile of gluten intake, the adjusted hazard ratios and 95% CIs for participants in the highest quintile of gluten intake were 1.16 (95% CI, 0.82-1.64; P-trend = .41) for CD and 1.04 (95% CI, 0.75-1.44; P-trend = .64) for UC. Adjusting for primary sources of gluten intake did not materially change our estimates.CONCLUSIONS: In three large adult US prospective cohorts, gluten intake was not associated with risk of CD or UC. Our findings are reassuring at a time when consumption of gluten has been increasingly perceived as a trigger for chronic gastrointestinal diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Crohn’s disease
- gluten
- inflammatory bowel disease
- ulcerative colitis
Publication and Content Type
- ref (subject category)
- art (subject category)
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Lopes, Emily W.
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Lebwohl, Benjami ...
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Burke, Kristin E ...
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Ivey, Kerry L.
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Ananthakrishnan, ...
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Lochhead, Paul
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Richter, James M ...
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Ludvigsson, Jona ...
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Willett, Walter ...
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Chan, Andrew T.
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Khalili, Hamed
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Clinical Gastroe ...
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Örebro University
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Karolinska Institutet