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Undiagnosed SARS-Co...
Undiagnosed SARS-CoV-2 infection and outcome in patients with acute MI and no COVID-19 symptoms
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- Akhtar, Zubair (författare)
- Infectious Diseases Division, ICDDRB, Dhaka, Dhaka District, Bangladesh
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- Chowdhury, Fahmida (författare)
- Infectious Diseases Division, ICDDRB, Dhaka, Dhaka District, Bangladesh
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- Aleem, Mohammad Abdul (författare)
- Infectious Diseases Division, ICDDRB, Dhaka, Dhaka District, Bangladesh; Biosecurity Research Program, Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia
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- Ghosh, Probir Kumar (författare)
- Infectious Diseases Division, ICDDRB, Dhaka, Dhaka District, Bangladesh
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- Rahman, Mahmudur (författare)
- Infectious Diseases Division, ICDDRB, Dhaka, Dhaka District, Bangladesh
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- Rahman, Mustafizur (författare)
- Infectious Diseases Division, ICDDRB, Dhaka, Dhaka District, Bangladesh
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- Hossain, Mohammad Enayet (författare)
- Infectious Diseases Division, ICDDRB, Dhaka, Dhaka District, Bangladesh
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- Sumiya, Mariya Kibtiya (författare)
- Infectious Diseases Division, ICDDRB, Dhaka, Dhaka District, Bangladesh
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- Islam, A. K. M. Monwarul (författare)
- Department of Cardiology, National Institute of Cardiovascular Diseases Dhaka (NICVD), Dhaka, Bangladesh
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- Uddin, Mir Jamal (författare)
- Department of Cardiology, National Institute of Cardiovascular Diseases Dhaka (NICVD), Dhaka, Bangladesh
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- MacIntyre, C. Raina (författare)
- Biosecurity Research Program, Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia
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- Cajander, Sara, 1980- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Infectious Diseases
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- Fröbert, Ole, 1964- (författare)
- Department of Cardiology, Örebro University Hospital, Orebro, Swede
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(creator_code:org_t)
- 2021-04-02
- 2021
- Engelska.
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Ingår i: Open heart. - : BMJ Publishing Group Ltd. - 2053-3624. ; 8:1
- Relaterad länk:
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https://doi.org/10.1...
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https://openheart.bm...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: We aimed to determine the prevalence and outcome of occult infection with SARS-CoV-2 and influenza in patients presenting with myocardial infarction (MI) without COVID-19 symptoms.METHODS: We conducted an observational study from 28 June to 11 August 2020, enrolling patients admitted to the National Institute of Cardiovascular Disease Hospital, Dhaka, Bangladesh, with ST-segment elevation MI (STEMI) or non-ST-segment elevation MI who did not meet WHO criteria for suspected COVID-19. Samples were collected by nasopharyngeal swab to test for SARS-CoV-2 and influenza virus by real-time reverse transcriptase PCR. We followed up patients at 3 months (13 weeks) postadmission to record adverse cardiovascular outcomes: all-cause death, new MI, heart failure and new percutaneous coronary intervention or stent thrombosis. Survival analysis was performed using the Kaplan-Meier method.RESULTS: We enrolled 280 patients with MI, 79% male, mean age 54.5±11.8 years, 140 of whom were diagnosed with STEMI. We found 36 (13%) to be infected with SARS-CoV-2 and 1 with influenza. There was no significant difference between mortality rate observed among SARS-CoV-2 infected patients compared with non-infected (5 (14%) vs 26 (11%); p=0.564). A numerically shorter median time to a recurrent cardiovascular event was recorded among SARS-CoV-2 infected compared with non-infected patients (21 days, IQR: 8-46 vs 27 days, IQR: 7-44; p=0.378).CONCLUSION: We found a substantial rate of occult SARS-CoV-2 infection in the studied cohort, suggesting SARS-CoV-2 may precipitate MI. Asymptomatic patients with COVID-19 admitted with MI may contribute to disease transmission and warrants widespread testing of hospital admissions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- COVID-19
- NSTEMI
- STEMI
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- ref (ämneskategori)
- art (ämneskategori)
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Akhtar, Zubair
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Chowdhury, Fahmi ...
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Aleem, Mohammad ...
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Ghosh, Probir Ku ...
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Rahman, Mahmudur
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Rahman, Mustafiz ...
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Hossain, Mohamma ...
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Sumiya, Mariya K ...
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Islam, A. K. M. ...
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Uddin, Mir Jamal
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MacIntyre, C. Ra ...
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Cajander, Sara, ...
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Fröbert, Ole, 19 ...
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Open heart
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Örebro universitet