Expression profile, molecular functions, and prognostic significance of miRNAs in primary colorectal cancer stem cells

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Fan, Chuan-WenInstitute of Digestive Surgery, Sichuan University, and Department of Gastrointestinal Surgery, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China; Department of Gastrointestinal Surgery and Breast and Thyroid Surgery, Minimally Invasive Surgery, West China Fourth Hospital, Sichuan University, Chengdu, China; Department of Oncology and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; Laboratory of Stem Cell Biology, West China Hospital, Sichuan University, Chengdu, China (author)

Expression profile, molecular functions, and prognostic significance of miRNAs in primary colorectal cancer stem cells

Article/chapterEnglish2021

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2021-04-01
Impact Journals LLC,2021
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LIBRIS-ID:oai:DiVA.org:oru-90995
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-90995URI
https://doi.org/10.18632/aging.202914DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-175991URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Funding Agencies:Sichuan Science and Technology Program 2017JY0061National Natural Science Foundation of China (NSFC) 81821002Oncology Clinics in Linköping
Funding Agencies|Sichuan Science and Technology Program [2017JY0061]; Science Fund for Creative Research Groups of the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81821002]; Swedish Cancer Foundation; Swedish Research CouncilSwedish Research CouncilEuropean Commission; Oncology Clinics in Linkoping
MicroRNAs (miRNAs) are known to drive the pathogenesis of colorectal cancer (CRC) via the regulation of cancer stem cells (CSCs). We studied the miRNA expression profile of primary CSCs isolated from patients with CRC (pCRCSCs). Compared to pCRCSC-derived differentiated cells, 98 differentially expressed miRNAs were identified in pCRCSCs. Target genes encoding pCRCSC-related miRNAs were identified using a combination of miRNA target databases and miRNA-mRNA regulatory networks from the same patient. The pCRCSC-related miRNA target genes were associated with pathways contributing to malignant phenotypes, including I-kappa B kinase/NF-kappa B signaling, signal transduction by p53 class mediator, Ras signaling, and cGMP-PKG signaling. The pCRCSC-related miRNA expression signature was independently associated with poor overall survival in both the training and validation cohorts. We have thus identified several pCRCSC-related miRNAs with oncogenic potential that could serve as prognostic biomarkers for CRC.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Geriatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Geriatrics hsv//eng
Cancer stem cells
colorectal cancer
miRNAs
prognosis
progression

Added entries (persons, corporate bodies, meetings, titles ...)

Lu, RanLaboratory of Stem Cell Biology, West China Hospital, Sichuan University, Chengdu, China,Sichuan Univ, Peoples R China (author)
Fang, ChaoInstitute of Digestive Surgery, Sichuan University, and Department of Gastrointestinal Surgery, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China,Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China (author)
Zhang, Xue-LiSchool of Medicine, Institute of Medical Sciences, Örebro University, Örebro, Sweden,Orebro Univ, Sweden (author)
Lv, Zhao-YingInstitute of Digestive Surgery, Sichuan University, and Department of Gastrointestinal Surgery, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China,Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China (author)
Li, YuanInstitute of Digestive Surgery, Sichuan University, and Department of Gastrointestinal Surgery, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China,Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China (author)
Zhang, Hong,1957-Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden,Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China(Swepub:oru)hzg (author)
Zhou, Zong-GuangInstitute of Digestive Surgery, Sichuan University, and Department of Gastrointestinal Surgery, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China (author)
Mo, Xian-MingLaboratory of Stem Cell Biology, West China Hospital, Sichuan University, Chengdu, China,Sichuan Univ, Peoples R China (author)
Sun, Xiao-FengLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US(Swepub:liu)xiasu45 (author)
Fan, ChuanwenLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China(Swepub:liu)chufa37 (author)
Institute of Digestive Surgery, Sichuan University, and Department of Gastrointestinal Surgery, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China; Department of Gastrointestinal Surgery and Breast and Thyroid Surgery, Minimally Invasive Surgery, West China Fourth Hospital, Sichuan University, Chengdu, China; Department of Oncology and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; Laboratory of Stem Cell Biology, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Stem Cell Biology, West China Hospital, Sichuan University, Chengdu, China (creator_code:org_t)

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In:Aging: Impact Journals LLC13:8, s. 12067-120851945-4589

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