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Sökning: L773:1873 1708 OR L773:0890 6238 > The brominated flam...

  • Bereketoglu, CeyhunBiology, The Life Science Center, School of Science and Technology, Örebro University, Örebro, Sweden,Biology, The Life Science Center (författare)

The brominated flame retardants TBECH and DPTE alter prostate growth, histology and gene expression patterns in the mouse

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • Elsevier,2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-91042
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-91042URI
  • https://doi.org/10.1016/j.reprotox.2021.04.002DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-182483URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agency:Örebro University  
  • The brominated flame retardants (BFRs), 1,2-dibromo-4-(1,2 dibromoethyl)cyclohexane (TBECH) and 2,3-dibromopropyl-2,4,6-tribromophenyl ether (DPTE) bind to the androgen receptor (AR). In vitro bioassays have shown that TBECH is a potent androgen agonist while DPTE is a potent AR antagonist. Both TBECH and DPTE alter gene expression associated with AR regulation. However, it remains to be determined if TBECH and DPTE can affect the prostate. For this reason, we exposed CD1 mice to a 1:1 mixture of TBECH diastereomers α and β, a 1:1 mixture of γ and δ, and to DPTE, and tested their effects on prostate growth, histology and gene expression profiles. Castrated (C) mice were used to study the androgenic effects of TBECHαβ and TBECHγδ while the antagonistic effects of DPTE were studied in non-castrated (NC) mice. We observed that testosterone and TBECHγδ increased body and prostate weights while TBECHαβ affected neither of them; and that DPTE had no effect on body weight but reduced prostate weight drastically. Histomorphometric analysis of the prostate revealed epithelial and glandular alterations in the TBECHγδ group comparable to those in testosterone group while alterations in the TBECHαβ group were less pronounced. DPTE displayed androgen antagonist activity reminiscent of castration. The transcription profile of the prostate was altered by castration and exposure to testosterone and to TBECHγδ reversed several of these changes. Testosterone and TBECHγδ also regulated the expression of several androgen responsive genes implicated in prostate growth and cancer. While DPTE resulted in a drastic reduction in prostate weight, it only affected a small number of genes. The results indicate that TBECHγδ and DPTE are of high human health concern as they may contribute to changes in prostate growth, histology and function.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Modig, Carina,1963-Örebro universitet,Institutionen för naturvetenskap och teknik,Biology, The Life Science Center, School of Science and Technology, Örebro University, Örebro, Sweden(Swepub:oru)cmg (författare)
  • Pradhan, Ajay,1983-Örebro universitet,Institutionen för naturvetenskap och teknik,Biology, The Life Science Center, School of Science and Technology, Örebro University, Örebro, Sweden(Swepub:oru)aypn (författare)
  • Andersson, Patrik L.Umeå universitet,Kemiska institutionen(Swepub:umu)paan0001 (författare)
  • Stasinopoulou, SotiriaMolecular Endocrinology Program, Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece (författare)
  • Mitsiou, Dimitra J.Molecular Endocrinology Program, Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece (författare)
  • Alexis, Michael N.Molecular Endocrinology Program, Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece (författare)
  • Olsson, Per-Erik,1957-Örebro universitet,Institutionen för naturvetenskap och teknik,Biology, The Life Science Center, School of Science and Technology, Örebro University, Örebro, Sweden(Swepub:oru)pkon (författare)
  • Biology, The Life Science Center, School of Science and Technology, Örebro University, Örebro, SwedenBiology, The Life Science Center (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Reproductive Toxicology: Elsevier102, s. 43-550890-62381873-1708

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